{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:39:50Z","timestamp":1773031190276,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Behcet's disease (BD) is a chronic inflammatory disease characterized by recurrent oral and genital ulcerations and ocular lesions. Subclinical cardiac involvement may develop in BD patients. We aimed to evaluate subclinical left ventricular (LV) and right ventricular (RV) systolic dysfunction in BD patients without any apparent cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 50 BD patients (43.8 \u00b1 9.7 years, 59% men) and 30 healthy controls (45.4 \u00b1 8.2 years, 60% men). Conventional echocardiography, tissue Doppler imaging, and velocity vector imaging\u2010based strain measurements were performed to analyze LV and RV systolic functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LV isovolumic myocardial acceleration, peak systolic velocity during isovolumic contraction (isovolumic contraction velocity), were significantly lower, while myocardial performance index was increased in BD patients. RV peak systolic velocity, isovolumic myocardial acceleration, and isovolumic contraction velocity were also markedly lower in BD patients. LV and RV longitudinal peak systolic strain and strain rate were significantly lower in patients than in controls, demonstrating subclinical ventricular systolic dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ventricular long\u2010axis functions are important markers of myocardial contractility. Novel echocardiographic techniques may provide additional data for detecting early deterioration in ventricular systolic function in patients with BD. \u00a9 2012 Wiley Periodicals, Inc. <jats:italic>J Clin Ultrasound<\/jats:italic> <jats:bold>41<\/jats:bold>:347\u2013353, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.21985","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T21:30:58Z","timestamp":1346535058000},"page":"347-353","source":"Crossref","is-referenced-by-count":7,"title":["Subclinical left and right ventricular systolic dysfunction in behcet's disease: A combined tissue doppler and velocity vector imaging study"],"prefix":"10.1002","volume":"41","author":[{"given":"Selen","family":"Yurdakul","sequence":"first","affiliation":[{"name":"Florence Nightingale Hospital Cardiology Division Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vefa 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