{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T02:28:09Z","timestamp":1787711289025,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T00:00:00Z","timestamp":1351814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Metformin has been shown to be an effective treatment for anovulatory polycystic ovary syndrome (PCOS) patients in terms of menstrual cyclicity, ovulation, and pregnancy, as well as reduction of early miscarriage rate. The aim of the study is to assess the effect of metformin on the endometrial vascular indices in anovulatory obese PCOS women using three\u2010dimensional power Doppler sonography (3DPDUS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was set to determine the beneficial effects of metformin on PCOS patients. Fifty anovulatory obese PCOS patients were compared with another 50 healthy volunteers who were age\u2010 and body mass index\u2010matched (control group). PCOS patients were treated with metformin (Glucophage; MerckSerono) 850 mg 3 times a day for 6 months. Assessment of the endometrial thickness and volume, uterine Doppler indices, and Doppler vascular indices of the endometrium and subendometrium in the periovulatory and midluteal phases were performed with 3DPDUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant increase in the endometrial thickness, endometrial volume, and endometrial and subendometrial vascularity indices (vascularization index, flow index, vascularization flow index) after 6 months of metformin treatment in PCOS women, whereas there was no change in the resistance index and the pulsatility index of the uterine artery in both periovulatory and midluteal phases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Metformin, owing to its metabolic, endocrine, vascular, and anti\u2010inflammatory effects, improves markers of endometrial receptivity. \u00a9 2012 Wiley Periodicals, Inc. J Clin Ultrasound, 41:275\u2013282, 2013<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22006","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T05:26:00Z","timestamp":1351833960000},"page":"275-282","source":"Crossref","is-referenced-by-count":20,"title":["Effect of metformin treatment on endometrial vascular indices in anovulatory obese\/overweight women with polycystic ovarian syndrome using three\u2010dimensional power doppler ultrasonography"],"prefix":"10.1002","volume":"41","author":[{"given":"Iman Abdel","family":"Mohsen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty Of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Elkattan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty Of Medicine Cairo University Cairo 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