{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:24:35Z","timestamp":1696397075940},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study was to investigate the sonographic (US) appearances of submandibular glands in patients with nasopharyngeal carcinoma after external beam radiotherapy (RT) and compare them with those of healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 81 nasopharyngeal carcinoma patients treated with RT and 66 healthy subjects were recruited and underwent submandibular gland US. Bilateral submandibular glands were assessed for their size, echogenicity, echogenicity margin sharpness, and echotexture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean \u00b1 SD transverse dimension of submandibular glands in patients treated with RT (2.5 \u00b1 0.4 cm) was significantly smaller than that of healthy subjects (3.3 \u00b1 0.4 cm) (<jats:italic>p<\/jats:italic> &lt; 0.05). Submandibular glands in patients treated with RT tended to be heterogeneous (72%) with hypoechoic areas (46%) and ill\u2010defined margins (89%). However, there were no statistically significant differences in echogenicity and conspicuity of intraglandular ducts of submandibular glands between patients and healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RT\u2010induced changes of the submandibular glands were demonstrated on US. \u00a9 2012 Wiley Periodicals, Inc. <jats:italic>J Clin Ultrasound<\/jats:italic>, 41:472\u2013478, 2013;<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22017","type":"journal-article","created":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T09:22:47Z","timestamp":1354353767000},"page":"472-478","source":"Crossref","is-referenced-by-count":2,"title":["Sonographic appearance of submandibular glands in patients treated with external beam radiotherapy for nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"41","author":[{"given":"Sammy C.H.","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Health Technology and Informatics The Hong Kong Polytechnic University Hunghom, Kowloon Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.C.","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics The Hong Kong Polytechnic University Hunghom, Kowloon Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora L.W.","family":"Kwong","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Queen Mary Hospital The University of Hong Kong Pokfulam Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent W.C.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics The Hong Kong Polytechnic University Hunghom, Kowloon Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf179"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.08.004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00092-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0b013e3181572b3a"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1322"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2007.02.016"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.09.012"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(94)01491-K"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.58"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00369-X"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.02838.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-997739"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02256.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2006.10.011"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/3577837"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00421-G"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01254473"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841858709177425"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00247-3"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-4328(01)00004-X"},{"key":"e_1_2_5_22_1","first-page":"S66.e1","volume-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod","author":"Shiboski CH","year":"2007"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90171-Y"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcu.22017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.22017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:08:08Z","timestamp":1696331288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.22017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/jcu.22017"],"URL":"https:\/\/doi.org\/10.1002\/jcu.22017","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}