{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:44:37Z","timestamp":1761561877310},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2014,11,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>In a retrospective observational study, we evaluated the feasibility and safety of medical therapy with transabdominal ultrasound\u2010guided injection of methotrexate (MTX) into the gestational sac (GS) in patients with interstitial ectopic pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen interstitial ectopic pregnancies were treated with transabdominal ultrasound\u2010guided injection of MTX (25 mg). All patients were hemodynamically stable. In all patients, the 10\u2010cm distance between the GS and vaginal fornices was \u226510 cm, making transvaginal injection difficult. To evaluate feasibility and safety of the procedure, we assessed complications clinically and with imaging during a 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all 14 patients, MTX injected locally into the GS successfully terminated the interstitial pregnancy, thereby avoiding surgery. There was no complications during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The successful outcome in our patients suggests that the transabdominal route is feasible and safe as a nonsurgical option for terminating an ectopic interstitial pregnancy in patients in whom the transvaginal route is contraindicated or difficult, provided the patients are properly selected and operators have sufficient experience with the technique. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>J Clin Ultrasound<\/jats:italic> <jats:bold>42<\/jats:bold>:522\u2013526, 2014<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22185","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T07:42:56Z","timestamp":1402645376000},"page":"522-526","source":"Crossref","is-referenced-by-count":13,"title":["Transabdominal ultrasound\u2010guided injection of methotrexate in the treatment of ectopic interstitial pregnancies"],"prefix":"10.1002","volume":"42","author":[{"given":"Marialuisa","family":"Framarino\u2010dei\u2010Malatesta","sequence":"first","affiliation":[{"name":"Department of Gynaecological Obstetrical, and Urological Sciences, Umberto I Hospital, University of Rome Sapienza  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Piccioni","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Obstetrical, and Urological Sciences, Umberto I Hospital, University of Rome Sapienza  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Derme","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Obstetrical, and Urological Sciences, Umberto I Hospital, University of Rome Sapienza  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta Fabiana","family":"Polidori","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Obstetrical, and Urological Sciences, Umberto I Hospital, University of Rome Sapienza  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Tibaldi","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Obstetrical, and Urological Sciences, Umberto I Hospital, University of Rome Sapienza  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Iannini","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Obstetrical, and Urological Sciences, Umberto I Hospital, University of Rome Sapienza  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Masselli","sequence":"additional","affiliation":[{"name":"Radiology Dea Department Umberto I Hospital, University of Rome Sapienza  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"15","article-title":"Diagnosis and treatment of ectopic pregnancy","volume":"257","author":"Epee\u2010Bekima M","year":"2013","journal-title":"Practitioner"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.06.024"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00242-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31802f4f79"},{"key":"e_1_2_5_6_1","first-page":"675","article-title":"Application of a rapid serum beta\u2010hCG assay in the early diagnosis of the ectopic pregnancies","volume":"10","author":"Massart C","year":"1981","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2008.12.011"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/11.2.420"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.07.054"},{"key":"e_1_2_5_10_1","first-page":"37","article-title":"Transabdominal intralesional injection of methotrexate in two angular live ectopic pregnancies","volume":"1","author":"Framarino dei Malatesta M","year":"2007","journal-title":"J Prenat Med"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000109218.24211.79"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2004.00025c.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.12.2649"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12342"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.06.013"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13020131.x"},{"key":"e_1_2_5_17_1","first-page":"142","article-title":"Low\u2010dose methotrexate treatment for interstitial pregnancy. 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