{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:27:47Z","timestamp":1761823667689},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess whether patient comfort could be increased by adding procedural sedation and analgesia (PSAA) to periprostatic nerve block (PNB) in patients undergoing transrectal ultrasound\u2010guided prostatic biopsy (TRUS\u2010PB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, randomized (1:2) trial comparing PNB with the combination of PSAA+PNB in patients undergoing TRUS\u2010PB. PNB was achieved by using lidocaine gel and lidocaine and bipuvacaine infiltration. PSAA\u2010treated patients received midazolam and remifentanil. All biopsies were standardized and performed in a fully equipped endourology suite. PSAA was delivered by an anesthesiology nurse in the presence and availability of an anesthesiologist. An orally administered numeric scale of 0\u201310 was used to assess the patient's pain, and a visual scale of 0\u20134 was used to quantify their satisfaction. Pain and satisfaction scores were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data on 331 patients were analyzed: 235 received PNB, and 96 received PSAA+PNB. Distribution within the groups by age, prostate\u2010specific antigen serum levels, prostate volume, and number of cores obtained was similar. Airway insertion was required in 4 of 96 patients in PSAA+PNB arm (4%), with no other complications related to sedation. The average pain level was significantly lower in the PSAA+PNB group than it was in the PNB group (0.88 versus 1.31; <jats:italic>p<\/jats:italic>\u2009=\u20090.008). The satisfaction level was high (3.5) and alike in the two groups; however, significantly more patients reported a perfect score of 4 in the PSAA+PNB arm (<jats:italic>p<\/jats:italic>\u2009=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PSAA with midazolam and remifentanil used as an adjunct to the standard PNB is safe and effective during TRUS\u2010PB. Patients undergoing PSAA in addition to PNB experienced significantly less pain and higher satisfaction scores than did those given PNB alone. \u00a9 2014 Wiley Periodicals, Inc. <jats:italic>J Clin Ultrasound<\/jats:italic> 43:288\u2013294, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22227","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T06:38:21Z","timestamp":1409035101000},"page":"288-294","source":"Crossref","is-referenced-by-count":6,"title":["Procedural sedation and analgesia as an adjunct to periprostatic nerve block for prostate biopsy: A prospective randomized trial"],"prefix":"10.1002","volume":"43","author":[{"given":"T\u00fcnkut","family":"Do\u011fanca","sequence":"first","affiliation":[{"name":"Department of Urology Suluova State Hospital Amasya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdurrahman","family":"Savsin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Istanbul Cerrahpa\u015fa School of Medicine Fatih Istanbul Turkey 34300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarper","family":"Erdo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Istanbul Cerrahpa\u015fa School of Medicine Fatih Istanbul Turkey 34300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatis","family":"Altindas","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Istanbul Cerrahpa\u015fa School of Medicine Fatih Istanbul Turkey 34300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Urology Palandoken State Hospital Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birsel","family":"Ekici","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Istanbul Cerrahpa\u015fa School of Medicine Fatih Istanbul Turkey 34300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"\u00d6bek","sequence":"additional","affiliation":[{"name":"Department of Urology University of Istanbul Cerrahpa\u015fa School of Medicine Fatih Istanbul Turkey 34300"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62255-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1997.00120.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02221.x"},{"key":"e_1_2_7_5_1","first-page":"61","article-title":"for the European Association of Urology. 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