{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:28:22Z","timestamp":1781789302294,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Our aim was to evaluate the rate of occurrence of chromosomal abnormalities, associated findings, and outcome in a series of cases of prenatally diagnosed clubfoot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of all cases of clubfoot diagnosed prenatally in the ultrasound unit of a French tertiary center from January 2004 through December 2011. Clubfoot was scored as complex or isolated depending on the presence or absence of another structural abnormality observed on sonographic examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 90 fetuses prenatally diagnosed with clubfoot were included in this study. Thirty\u2010four cases were considered complex (38%) and 56 were considered isolated (62%). A chromosomal abnormality was identified in 10 of 33 of the fetuses with complex clubfoot and in 1 of 45 of those with isolated clubfoot (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Clubfoot was associated with a poor outcome in 5 of 52 cases of isolated clubfoot and in 31 of 34 cases associated with other structural defects (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The deformity was bilateral in 62 cases (69%) and unilateral in 28 (31%). No statistically significantly higher rate of poor outcome was identified when the deformity occurred bilaterally nor was a significantly higher rate of chromosomal abnormality noted in this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aneuploidy and adverse pregnancy outcomes occur more commonly in prenatally diagnosed cases of complex clubfoot than in those of isolated clubfoot. Fetal karyotyping is required in cases of complex clubfoot, but the need for that procedure in isolated clubfoot remains controversial. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>J Clin Ultrasound<\/jats:italic> <jats:bold>44<\/jats:bold>:100\u2013105, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22275","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T16:56:36Z","timestamp":1436892996000},"page":"100-105","source":"Crossref","is-referenced-by-count":24,"title":["Prenatal diagnosis of clubfoot: Chromosomal abnormalities associated with fetal defects and outcome in a tertiary center"],"prefix":"10.1002","volume":"44","author":[{"given":"Benjamin","family":"Viaris de le Segno","sequence":"first","affiliation":[{"name":"CHU de Caen, D\u00e9partement d'Obst\u00e9trique Gyn\u00e9cologie et M\u00e9decine de la Reproduction Caen 14000 France"},{"name":"CHU de Caen, D\u00e9partement de Statistiques Avenue Cl\u00e9menceau, 14033 Caen Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Gruchy","sequence":"additional","affiliation":[{"name":"CHU de Caen, D\u00e9partement de Statistiques Avenue Cl\u00e9menceau, 14033 Caen Cedex 9 France"},{"name":"CHU de Caen, D\u00e9partement de Cytog\u00e9n\u00e9tique Pr\u00e9natale Caen 14000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Bronfen","sequence":"additional","affiliation":[{"name":"CHU de Caen, D\u00e9partement d'Orthop\u00e9die P\u00e9diatrique 14033 Caen Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Dolley","sequence":"additional","affiliation":[{"name":"CHU de Caen, D\u00e9partement d'Obst\u00e9trique Gyn\u00e9cologie et M\u00e9decine de la Reproduction Caen 14000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Leporrier","sequence":"additional","affiliation":[{"name":"CHU de Caen, D\u00e9partement de Statistiques Avenue Cl\u00e9menceau, 14033 Caen Cedex 9 France"},{"name":"CHU de Caen, D\u00e9partement de Cytog\u00e9n\u00e9tique Pr\u00e9natale Caen 14000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Creveuil","sequence":"additional","affiliation":[{"name":"CHU de Caen, D\u00e9partement de Statistiques Avenue Cl\u00e9menceau, 14033 Caen Cedex 9 France"},{"name":"Universit\u00e9 de Caen Basse\u2010Normandie, Esplanade de la Paix 14032 Caen Cedex 5 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Benoist","sequence":"additional","affiliation":[{"name":"CHU de Caen, D\u00e9partement d'Obst\u00e9trique Gyn\u00e9cologie et M\u00e9decine de la Reproduction Caen 14000 France"},{"name":"CHU de Caen, D\u00e9partement de Statistiques Avenue Cl\u00e9menceau, 14033 Caen Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980901)79:2<90::AID-AJMG3>3.0.CO;2-R"},{"key":"e_1_2_5_3_1","first-page":"464","article-title":"Talipes equinovarus. A review of eighty\u2010four cases after completion of treatment","volume":"46","author":"Wynne\u2010Davies R","year":"1964","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-199901000-00003"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00780.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1984"},{"key":"e_1_2_5_7_1","first-page":"117","article-title":"Congenital clubfoot: pathoanatomy and treatment","volume":"36","author":"Carroll NC","year":"1987","journal-title":"Instr Course Lect"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B7.16076"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00582-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870140907"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12020103.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70445-4"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1998.tb03071.x"},{"key":"e_1_2_5_14_1","first-page":"258","article-title":"Is fetal karyotyping justified after prenatal diagnosis of isolated clubfoot?","volume":"28","author":"Perthus I","year":"2008","journal-title":"[Article in French with English abstract.] Bulletin \u00c9pid\u00e9miologique Hebdomadaire Th\u00e9matique"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcu.22275","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.22275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T06:51:45Z","timestamp":1696488705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.22275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1002\/jcu.22275"],"URL":"https:\/\/doi.org\/10.1002\/jcu.22275","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]}}}