{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T13:10:12Z","timestamp":1696425012491},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"This work was supported by the 2015 Inje University research grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate gray\u2010scale and color Doppler sonographic (US) features of complex fibroadenoma (FA), according to the Breast Imaging\u2010Reporting and Data System (BI\u2010RADS) lexicon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2010 through 2013, 586 women with FAs were seen; 101 (17%) of those lesions were diagnosed as complex FAs on percutaneous needle biopsy or surgery. Among the patients with complex FAs, 67 who had US examination results available were included in this study. In addition, the results from 98 women who had simple FAs were included as controls. US features were retrospectively analyzed by two breast radiologists in consensus for shape, margin, echogenicity, posterior acoustic pattern, boundary, orientation, and associated findings. They also reassessed the BI\u2010RADS category for FAs. Color Doppler US examination results were classified according to the amount of vascularity as absent, moderate, or marked.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complex FA were larger than simple FAs were (14.5 cm versus 12.1 cm, <jats:italic>p<\/jats:italic> &gt; 0.05). On univariate analysis, a round to irregular shape, an uncircumscribed margin, the presence of associated findings, and BI\u2010RADS categorization as 4a and 4b were more frequently revealed in complex than in simple FAs (<jats:italic>p<\/jats:italic> &lt; 0.05). Multivariate analysis revealed that the tumor margin was a predictive factor for complex FA (odds ratio: 6.08; 95% confidence interval: 1.14\u201332.49, <jats:italic>p<\/jats:italic> &lt; 0.05). On color Doppler US, the complex FAs had higher degrees of vascularity than simple FA (<jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Complex FAs, in comparison with simple FAs, tend to have more aggressive features and to be in higher BI\u2010RADS categories on US examination. \u00a9 2015 Wiley Periodicals, Inc. <jats:italic>J Clin Ultrasound<\/jats:italic> <jats:bold>43<\/jats:bold>:556\u2013562, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22278","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T11:03:29Z","timestamp":1437476609000},"page":"556-562","source":"Crossref","is-referenced-by-count":6,"title":["Gray\u2010scale and color Doppler sonographic features of complex fibroadenomas of the breast"],"prefix":"10.1002","volume":"43","author":[{"given":"Kwang Hwi","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiology Haeundae Paik Hospital Inje University College of Medicine 875, Haeun\u2010daero, Haeundae\u2010gu Busan 612\u2010896 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Haeundae Paik Hospital Inje University College of Medicine 875, Haeun\u2010daero, Haeundae\u2010gu Busan 612\u2010896 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Mi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology Busan Paik Hospital Inje University College of Medicine Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woogyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Haeundae Paik Hospital Inje University College of Medicine 875, Haeun\u2010daero, Haeundae\u2010gu Busan 612\u2010896 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hee","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Radiology Haeundae Paik Hospital Inje University College of Medicine 875, Haeun\u2010daero, Haeundae\u2010gu Busan 612\u2010896 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Woon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiology Haeundae Paik Hospital Inje University College of Medicine 875, Haeun\u2010daero, Haeundae\u2010gu Busan 612\u2010896 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Haeundae Paik Hospital Inje University College of Medicine 875, Haeun\u2010daero, Haeundae\u2010gu Busan 612\u2010896 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Jung","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Radiology Haeundae Paik Hospital Inje University College of Medicine 875, Haeun\u2010daero, Haeundae\u2010gu Busan 612\u2010896 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Jin","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Radiology Haeundae Paik Hospital Inje University College of Medicine 875, Haeun\u2010daero, Haeundae\u2010gu Busan 612\u2010896 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon\u2010Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Myongji Hospital Hwasu\u2010ro 14, Deogyang\u2010gu Goyang\u2010si Gyeonggi\u2010do 412\u2010270 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yedaun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Haeundae Paik Hospital Inje University College of Medicine 875, Haeun\u2010daero, Haeundae\u2010gu Busan 612\u2010896 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9776(03)00123-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1309\/F523-FMJV-W886-3J38"},{"key":"e_1_2_5_4_1","first-page":"187","volume-title":"Rosen's Breast Pathology","author":"Rosen 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