{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:46:10Z","timestamp":1773146770310,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T00:00:00Z","timestamp":1478908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2017,3,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare contrast\u2010enhanced ultrasonography (CEUS) using Sonazoid with Gd\u2010EOB\u2010DTPA\u2010enhanced MRI (EOB\u2010MRI) in the diagnosis of liver metastases in patients with colorectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 69 patients diagnosed with or suspected of having liver metastasis were enrolled. These hepatic lesions were diagnosed by histopathological examination after surgical resection or based on follow\u2010up using various imaging modalities. The diagnostic accuracies of CEUS and EOB\u2010MRI were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred thirty\u2010three lesions were detected. Of these lesions, 109 were diagnosed as liver metastases. Of the 133 lesions, 90.2% were detected on CEUS, and 98.5% on EOB\u2010MRI. One hundred nine lesions were diagnosed as liver metastasis. The areas under the receiver operating characteristic curve for diagnosis were 0.906 and 0.851 on CEUS and EOB\u2010MRI, respectively (<jats:italic>p<\/jats:italic> = 0.41). Sensitivity, specificity, positive predictive value (PPV), negative predictive value, and overall accuracy were 90.8%, 84.5%, 97.1%, 67.1%, and 90.2%, respectively, for CEUS, and 95.4%, 70.8%, 93.7%, 77.3%, and 91%, respectively, for EOB\u2010MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CEUS has a higher specificity and PPV for the diagnosis of liver metastasis than EOB\u2010MRI. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>J Clin Ultrasound<\/jats:italic> <jats:bold>45<\/jats:bold>:138\u2013144, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22421","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T16:07:40Z","timestamp":1479312460000},"page":"138-144","source":"Crossref","is-referenced-by-count":25,"title":["Comparison of contrast\u2010enhanced ultrasonograpy with Gd\u2010EOB\u2010DTPA\u2010enhanced MRI in the diagnosis of liver metastasis from colorectal cancer"],"prefix":"10.1002","volume":"45","author":[{"given":"Kazue","family":"Shiozawa","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Toho University Medical Center Omori Hospital, 6\u201011\u20101, Omorinishi Ota\u2010ku Tokyo 143\u20108541 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Toho University Medical Center Omori Hospital, 6\u201011\u20101, Omorinishi Ota\u2010ku Tokyo 143\u20108541 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ikehara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Toho University Medical Center Omori Hospital, 6\u201011\u20101, Omorinishi Ota\u2010ku Tokyo 143\u20108541 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