{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:48:14Z","timestamp":1772012894684,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2017,7,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Orthostatic hypotension (OH) is controversially regarded as the cause of orthostatic dizziness in Parkinson's disease (PD). We sought to evaluate whether cerebral autoregulation is an alternative cause for orthostatic dizziness in PD patients, using transcranial Doppler monitoring during head\u2010up tilting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five PD patients with dizziness, 13 PD patients without dizziness, and 10 age\u2010matched healthy controls were enrolled. Participants were divided into the following four groups: patients with dizziness and OH (group 1, n\u2009=\u200922), patients with dizziness but no OH (n\u2009=\u200923, group 2), patients without dizziness (n\u2009=\u200911, group 3), and age\u2010matched healthy controls (n\u2009=\u200910, group 4). All participants underwent transcranial Doppler and blood pressure monitoring for 10 minutes during the head\u2010up tilt test. Changes in the cerebral blood flow velocity (CBFV) in the middle cerebral artery and the mean blood pressure (mBP) within 3 minutes after head\u2010up tilting were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Group 1 showed a significantly higher change in mBP (\u221216.3\u2009\u00b1\u200910.8 mmHg) than groups 2 (\u22122.6\u2009\u00b1\u20094.9), 3 (\u22122.2\u2009\u00b1\u20093.6), or 4 (1.8\u2009\u00b1\u20096.0) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). However, groups 3 (4.6\u2009\u00b1\u20093.0\u2009cm\/s) and 4 (\u22124.2\u2009\u00b1\u20092.5) showed a significantly smaller change in CBFV than groups 1 (\u22129.0\u2009\u00b1\u20094.2) and 2 (\u22128.1\u2009\u00b1\u20095.1) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that cerebral hypoperfusion contributes to dizziness in PD patients despite a lack of OH. Transcranial Doppler monitoring during head\u2010up tilting may be a useful tool for evaluating dizziness in PD patients with or without OH. \u00a9 2016 Wiley Periodicals, Inc. <jats:italic>J Clin Ultrasound<\/jats:italic> <jats:bold>45<\/jats:bold>:337\u2013342, 2017;<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22452","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T10:20:23Z","timestamp":1491992423000},"page":"337-342","source":"Crossref","is-referenced-by-count":14,"title":["Orthostatic dizziness in Parkinson's disease is attributed to cerebral hypoperfusion: A transcranial doppler study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-5422","authenticated-orcid":false,"given":"Jinse","family":"Park","sequence":"first","affiliation":[{"name":"Department of Neurology Haeundae Paik Hospital, Inje University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee\u2010Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Hanyang University College of Medicine, Hanyang University, College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Haeundae Paik Hospital, Inje University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam Yeol","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Neurology Haeundae Paik Hospital, Inje University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Haeundae Paik Hospital, Inje University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyong Jin","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology Haeundae Paik Hospital, Inje University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Haeundae Paik Hospital, Inje University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wooyoung","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Neurology Gangneung Asan Hospital, University of Ulsan College of Medicine Gangneung Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Soonchunhyang University College of Medicine Seoul Republic of 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