{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:14:14Z","timestamp":1788898454645,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the relationship between nonalcoholic fatty liver disease (NAFLD) on sonography (US) and the risk of coronary heart disease (CHD) as well as the predictive value of US\u2010diagnosed NAFLD to determine intermediate\/high CHD risk compared with as well as in combination on with NAFLD fibrosis score (NFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 1,276 patients examined between November 2015 and August 2016. NAFLD was categorized as absent, mild, moderate, or severe based on liver\u2010to\u2010kidney echogenicity, visibility of intrahepatic vessel walls, and the diaphragm. The Framingham risk score (FRS) and NFS were used to predict CHD risk and hepatic fibrosis severity. Spearman correlation test, multivariate\u2010adjusted logistic regression analysis, and receiver operating characteristic curves were used for statistical evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FRS increased as NAFLD severity increased, and US\u2010determined NAFLD severity and FRS were highly positively correlated (<jats:italic>r<\/jats:italic>\u2009=\u20090.683, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The odds ratios for intermediate\/high CHD risk increased with increasing NAFLD severity. The predictive performance of US\u2010determined NAFLD severity for determining intermediate\/high CHD risk in NAFLD patients was 0.738. There was no significant difference between US\u2010determined NAFLD severity and NFS in terms of identifying intermediate\/high CHD risk (<jats:italic>p<\/jats:italic>\u2009=\u20090.88). However, the combination of US\u2010determined NAFLD severity and NFS significantly improved the ability to distinguish intermediate\/high CHD risk compared with that of US\u2010determined NAFLD severity or NFS alone (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>US\u2010determined NAFLD severity was well correlated with FRS and associated with the prevalence of intermediate\/high CHD risk. The combination of US\u2010determined NAFLD severity and NFS may be useful for predicting CHD risk. \u00a9 2017 Wiley Periodicals, Inc. <jats:italic>J Clin Ultrasound<\/jats:italic> <jats:bold>45<\/jats:bold>:391\u2013399, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22472","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T15:52:25Z","timestamp":1490716345000},"page":"391-399","source":"Crossref","is-referenced-by-count":16,"title":["Severity of nonalcoholic fatty liver disease on sonography and risk of coronary heart disease"],"prefix":"10.1002","volume":"45","author":[{"given":"Sun Hwa","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Sanggye Paik Hospital, Inje University College of Medicine 1342 Dongil\u2010ro Seoul Nowon\u2010gu 139\u2010707 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3775-5701","authenticated-orcid":false,"given":"Seong Jong","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Radiology Aerospace Medical Center, Republic of Korea Air Force Box 335\u201021, 635 Danjae\u2010ro Namil\u2010myeon, Cheongwon\u2010gun Chungcheongbuk\u2010do 363\u2010849 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Aerospace Medical Center, Republic of Korea Air Force Box 335\u201021, 635 Danjae\u2010ro Namil\u2010myeon, Cheongwon\u2010gun Chungcheongbuk\u2010do 363\u2010849 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Hwan","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Radiology Aerospace Medical Center, Republic of Korea Air Force Box 335\u201021, 635 Danjae\u2010ro Namil\u2010myeon, Cheongwon\u2010gun Chungcheongbuk\u2010do 363\u2010849 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Sung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine 149 Sangil\u2010dong Gangdong\u2010gu Seoul 134\u2010727 Republic of 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