{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:27:24Z","timestamp":1793298444821,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the influence of systemic sclerosis (SSc) on right ventricular (RV) remodeling by two\u2010 and three\u2010dimensional echocardiography (2DE and 3DE) and heart rate variability (HRV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five SSc patients and 35 age\u2010 and gender\u2010matched healthy controls underwent clinical examination, 24\u2010h Holter monitoring, and comprehensive 2DE and 3DE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>2DE RV global and RV free wall longitudinal strains, as well as 2DE RV endocardial, mid\u2010myocardial, and epicardial longitudinal strains were lower in SSc subjects, who exhibited greater 3DE RV volumes but lower 3DE RV ejection fraction than controls. HRV indices were impaired in SSc subjects. These differences in RV global and free wall longitudinal strain, layer\u2010specific strains, and ejection fraction, were associated with HRV indices independently of demographic, clinical, and echocardiographic parameters. Modified Rodnan Skin Score, clinical indicator of skin involvement in SSc, was associated with HRV parameters, RV layer\u2010specific mechanics, and RV ejection fraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SSc affects RV function and mechanics of all myocardial layers, as well as cardiac autonomic nervous function. HRV indices are significantly associated with RV function, RV deformation, and skin involvement in SSc patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22552","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T12:12:42Z","timestamp":1508847162000},"page":"188-194","source":"Crossref","is-referenced-by-count":15,"title":["Systemic sclerosis impacts right heart and cardiac autonomic nervous system"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6235-5152","authenticated-orcid":false,"given":"Marijana","family":"Tadic","sequence":"first","affiliation":[{"name":"Cardiology Department University Clinical Hospital Center \u201cDr. Dragisa Misovic\u2014Dedinje,\u201d Heroja Milana Tepica 1, Belgrade 11000 Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Zlatanovic","sequence":"additional","affiliation":[{"name":"Institute for Rheumatology Resavska 69, Belgrade 11000 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