{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:25:55Z","timestamp":1740104755661,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study the effects of terlipressin (TP) infusion on systemic perfusion, estimated with pulsed\u2010wave Doppler ultrasonography of systemic arteries, in a population of extremely low birth\u2010weight (ELBW) preterm infants with vasoactive\u2010resistant ductus arteriosus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, observational cohort included, during five years, 12 ELBW infants with hemodynamically significant patent ductus arteriosus and absent or reversed diastolic flow at Doppler ultrasonography of systemic arteries, despite treatment and high\u2010dose vasoactive support. We measured flow velocity of the anterior cerebral, right renal, and superior mesenteric arteries before and after TP infusion. Changes were evaluated by Spearman's rho coefficient analysis, Wilcoxon signed\u2010rank, and Friedman test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Time\u2010averaged mean velocity of the renal artery (<jats:italic>P<\/jats:italic>\u2009=\u2009.028) increased, while renal pulsatility (<jats:italic>P<\/jats:italic>\u2009=\u2009.010) and resistance (<jats:italic>P<\/jats:italic>\u2009=\u2009.004) indexes, and cerebral artery resistance index (<jats:italic>P<\/jats:italic>\u2009=\u2009.021) decreased after TP infusion. Time\u2010averaged mean velocity of the anterior cerebral artery proportionately increased with dopamine dose (rho\u2009=\u20090.678; <jats:italic>P<\/jats:italic>\u2009=\u2009.015), but showed opposite shifts after TP (rho\u2009=\u2009\u22120.662; <jats:italic>P<\/jats:italic>\u2009=\u2009.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These changes suggest that TP may improve systemic perfusion in the ELBW infants with vasoactive\u2010resistant ductus arteriosus.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22565","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T15:42:52Z","timestamp":1511970172000},"page":"202-208","source":"Crossref","is-referenced-by-count":1,"title":["Terlipressin\u2010induced modifications of <scp>D<\/scp>oppler ultrasound signals of systemic arteries in preterm infants with vasoactive\u2010resistant patent ductus arteriosus: A pilot study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-4298","authenticated-orcid":false,"given":"M.","family":"Radicioni","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit S.M. dellaMisericordia Hospital of Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Bini","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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