{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:49:17Z","timestamp":1777312157428,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Ultrasonographic contrast enhancement of carotid plaque (CECP) has been used to detect neovascularization of <jats:italic>vasa vasorum<\/jats:italic> and plaque. However, it is uncertain whether CECP can provide risk stratification of coronary artery disease (CAD). This study aimed to evaluate the relationship between CECP and manifestations of acute coronary syndrome (ACS) in established CAD patients and to explore the prognostic implication of CECP for cardiovascular (CV) clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A medical record review revealed that contrast\u2010enhanced ultrasonography was performed to evaluate carotid atherosclerosis in 209 coronary artery\u2010stented and 105 non\u2010stented patients. The rate of ACS manifestations was compared depending on contrast uptake patterns: grade 0, absent; grade 1, dot; and grade 2, diffuse pattern. CV primary outcomes were assessed during a mean 7.6 months of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Male sex, smoking, history of old myocardial infarction, intensive medications, and a favorable lipid profile were common in the stented versus non\u2010stented group. Patients with grade 2 CECP had a higher rate of ACS, greater plaque thickness, and class I\u2010II of Gray\u2010Weale plaque echogenicity. During follow\u2010up, 10 coronary revascularizations (nine ACSs), six strokes, and four heart failures occurred. Grade 2 CECP was more closely related with CV primary outcomes and showed a tendency toward more acute CV outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ACS manifestations were proportionate to CECP grade. Diffuse CECP uptake could be a risk factor for acute CV outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22638","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T04:28:39Z","timestamp":1539232119000},"page":"461-466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Implication of ultrasound contrast\u2010enhancement of carotid plaques in prevalence of acute coronary syndrome and occurrence of cardiovascular outcomes"],"prefix":"10.1002","volume":"46","author":[{"given":"Sang\u2010Woong","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Keimyung University Dongsan Medical Center  Daegu Republic of 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