{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T23:56:36Z","timestamp":1772322996024,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T00:00:00Z","timestamp":1538265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["Senior Investigator Award"],"award-info":[{"award-number":["Senior Investigator Award"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>International guidelines advocate intensive blood pressure (BP) lowering within 6 hours of acute intracerebral hemorrhage (ICH) to a target systolic BP of 130\u2010140\u2009mm Hg, though more intensive lowering may be associated with adverse outcome. Observational studies suggest impaired cerebral autoregulation (CA) following ICH. Transcranial Doppler ultrasonography (TCD), alongside continuous BP monitoring, provides a noninvasive bedside investigation that offers detailed perspectives on physiological perturbations post\u2010acute ICH. This systematic review and meta\u2010analysis focuses on all TCD studies of CA in ICH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, EMBASE, and CENTRAL were searched for studies of hemorrhagic stroke and blood flow measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies met inclusion criteria (293 ICH patients); CA was impaired up to 12\u2010days post\u2010acute ICH. Impaired CA was evidenced by reduced transfer function analysis phase and higher mean flow correlation values: these were associated with worsened clinical parameters including ICH\u2010volume and Glasgow Coma Scale. Meta\u2010analysis of CBV demonstrated that, compared to controls, mean CBV was significantly lower in the ipsilateral (49.7 vs 64.8\u2009cm\u2009s<jats:sup>\u22121<\/jats:sup>, <jats:italic>Z<\/jats:italic>\u2009=\u20094.26, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) and contralateral hemispheres following ICH (51.5 vs 64.8\u2009cm\u2009s<jats:sup>\u22121<\/jats:sup>, <jats:italic>Z<\/jats:italic>\u2009=\u20093.44, <jats:italic>P<\/jats:italic>\u2009=\u2009.0006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lower mean CBV in combination with impaired CA may have implications for more intensive BP lowering and warrants further studies examining such strategies on cerebral blood flow and its regulatory mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22645","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T05:59:10Z","timestamp":1538373550000},"page":"14-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cerebral autoregulation in hemorrhagic stroke: A systematic review and meta\u2010analysis of transcranial Doppler ultrasonography studies"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-9105","authenticated-orcid":false,"given":"Jatinder S.","family":"Minhas","sequence":"first","affiliation":[{"name":"Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences University of Leicester  Leicester United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronney B.","family":"Panerai","sequence":"additional","affiliation":[{"name":"Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences University of Leicester  Leicester United Kingdom"},{"name":"National Institute for Health Research Leicester Biomedical Research Centre University of Leicester  Leicester United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Ghaly","sequence":"additional","affiliation":[{"name":"Department of Stroke Medicine University Hospitals of Leicester NHS Trust  Leicester United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pip","family":"Divall","sequence":"additional","affiliation":[{"name":"Department of Stroke Medicine University Hospitals of Leicester NHS Trust  Leicester United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thompson G.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of 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