{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:39:36Z","timestamp":1779237576210,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004482","name":"Kuwait University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004482","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004482","name":"Kuwait University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004482","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We assessed the pattern of cerebral blood flow and the relationship between the different transcranial Doppler imaging (TCDI) vascular parameters in children with sickle cell disease (SCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three SCD pediatric patients with a stable condition (21 HbSS, 19 HbS\u03b2<jats:sup>0<\/jats:sup> Thal, and 3 HbSD), aged 10.1 \u00b1 3.9 years were studied. A control group of 26 with age and sex\u2010matched, were included for comparison. TCDI scanning was carried out using a phased array transducer of 1\u20103 MHz through the trans\u2010temporal window. Peak systolic velocity (PSV), end diastolic velocity (EDV), time\u2010averaged mean of the maximum velocity (TAMxV), pulsatility index (PI), and resistive index (RI) were in the anterior circle of Willis vessels and posterior cerebral artery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The highest mean\u2009\u00b1\u2009SD values for the middle cerebral artery PSV, EDV, TAMxV, PI, and RI were 130.30\u2009+\u200926.5, 145.0\u2009\u00b1\u200921.9; 58.60\u2009+\u200913.70, 67.90\u2009\u00b1\u200913.3; 84.90\u2009+\u200914.50, 94.80\u2009\u00b1\u200917.9; 0.95\u2009+\u20090.20, 0.80\u2009\u00b1\u20090.20; 0.58\u2009+\u20090.09, 0.50\u2009\u00b1\u20090.10 in the control and SCD groups, respectively. Independent <jats:italic>t<\/jats:italic>\u2010test showed significant difference (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) for all vascular parameters in all vessels in each side between both groups. There was a positive significant correlation between TAMxV, PSV, and EDV (<jats:italic>P<\/jats:italic>\u2009=\u2009.001, r\u2009=\u2009.96), and a negative significant correlation between TAMxV and PI in the SCD group (<jats:italic>P<\/jats:italic>\u2009=\u2009.001, r\u2009=\u2009\u2212.46) but not in the control group (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05, r\u2009=\u2009\u2212.62).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was a direct relationship between TAMxV and PSV and EDV, and an inverse relationship between TAMxV and PI in a group of SCD patients with normal TCDI values.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22663","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T05:48:30Z","timestamp":1542174510000},"page":"128-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pattern of cerebral blood flow and the interrelationship of vascular parameters of transcranial Doppler imaging in children with sickle cell disease"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5212-4553","authenticated-orcid":false,"given":"Akram M.","family":"Asbeutah","sequence":"first","affiliation":[{"name":"Department of Radiologic Sciences, Faculty of Allied Health Sciences Kuwait University  Sulaibikhat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah A.","family":"AlMajran","sequence":"additional","affiliation":[{"name":"Department of Community Medicine &amp; Behavioural Sciences, Health Sciences Centre, Faculty of Medicine Kuwait University  Sulaibikhat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adekunle","family":"Adekile","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Kuwait University  Sulaibikhat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"505","volume-title":"Handbook of Clinical Neurology: Vascular Diseases \u2010Part III","author":"Adams RJ","year":"1989"},{"key":"e_1_2_8_3_1","first-page":"160","volume-title":"Transcranial Doppler Ultrasonography","author":"Adams RJ","year":"1993"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.26719\/1999.5.6.1147"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029609352661"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630261003677213"},{"key":"e_1_2_8_7_1","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: rates and risk factors","volume":"91","author":"Ohene\u2010Frempong K","year":"1998","journal-title":"Blood"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-016-0622-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680490278402"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.07.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10776"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-004-1282-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v7.i2.52"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.183.4.1831117"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470100427"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2529"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.591818"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22099"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318279caae"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24758"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14680"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-8864-4_4"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.2.339"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.189.2.8105505"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000204216"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000203753"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000141506"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-017-0814-z"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcu.22663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.22663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T07:22:46Z","timestamp":1694676166000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.22663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/jcu.22663"],"URL":"https:\/\/doi.org\/10.1002\/jcu.22663","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,13]]},"assertion":[{"value":"2018-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}