{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:48:44Z","timestamp":1765356524955,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Blood hemoglobin concentration measurements using a spectrophotometric method (SpHb), and inferior vena cava ultrasonography (IVC\u2010US) are noninvasive methods used to follow\u2010up hemorrhages. We compared their efficacy using voluntary blood donation as a model of moderate (approx. 500\u2009mL) blood loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective observational study enrolling blood\u2010donor volunteers (BD) and matched controls, we recorded SpHb, IVC diameters, and vital signs. Changes in variables from baseline were compared between BD and controls using the paired <jats:italic>t<\/jats:italic> test and Wilcoxon signed rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 118 subjects in the BD group and 95 healthy subjects in the control group. Changes in IVC maximum diameter, IVC minimum diameter, pulse rate, mean arterial pressure, pulse pressure, and shock index, but not in other variables, were significantly different in the BD and the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). IVCmax \u22651.1\u2009mm yielded a 74% sensitivity and 77% specificity (PPV 79.8%, NPV 70.2%) in detecting early hemorrhage. With these cutoff values, IVCmax or PR reached a 90% sensitivity, while IVCmin and PR reached 98% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IVC ultrasound may be superior to SpHb in predicting blood loss and may be useful in addition to vital signs for its follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22709","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T05:24:29Z","timestamp":1552627469000},"page":"278-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A comparison of noninvasive methods for early detection of hemorrhage: Inferior vena cava ultrasonography and spectrophotometric hemoglobin levels"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-0172","authenticated-orcid":false,"given":"Adnan","family":"Yamanoglu","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Izmir Katip Celebi University, Ataturk Training and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nalan Gokce","family":"Celebi Yamanoglu","sequence":"additional","affiliation":[{"name":"Beykoz State Hospital Emergency Service  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozgur","family":"Sogut","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Health Sciences, Haseki Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Yigit","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Health Sciences, Haseki Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demet","family":"Tas","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Health Sciences, Haseki Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neslihan","family":"Sacl\u0131","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Health Sciences, Haseki Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih Esad","family":"Topal","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Izmir Katip Celebi University, Ataturk Training and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(03)00042-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.01.005"},{"volume-title":"Fluid and Blood Resuscitation in Emergency Medicine: A Comprehensive Study Guide","year":"2004","author":"Manning J","key":"e_1_2_10_4_1"},{"key":"e_1_2_10_5_1","first-page":"103","volume-title":"Advanced Trauma Life Support Manual","author":"Committee on Trauma","year":"1997"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000197925.92635.56"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2004.01.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318068d72b"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10140-007-0602-4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2010.06.535"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-201106001-00081"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-015-9660-4"},{"key":"e_1_2_10_13_1","unstructured":"GoldflamK SaulT LewissR.ACEP Now 2011: Inferior vena cava ultrasound.https:\/\/www.acepnow.com\/article\/inferior-vena-cava-ultrasound\/. 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