{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:18:28Z","timestamp":1747149508263,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vasculopathy, as occurring in sickle cell disease (SCD), can affect celiac and mesenteric arteries and result in stenosis, with elevated peak systolic velocity (PSV) on Doppler ultrasonography. In six subjects with confirmed SCD in steady state, routine Doppler ultrasonographic examination discovered features of celiac artery (CA) or superior mesenteric artery (SMA) stenosis with CA PSV\u2009&gt;200\u2009cm\/s (median = 222.8 cm\/s; range = 201.5\u2010427.1 cm\/s) and\/or SMA PSV\u2009&gt;275\u2009cm\/s (median 183.2 cm\/s; range = 87.8\u2010289.3 cm\/s). Among the six subjects, five had elevated soluble P\u2010selectin values (median 72.55\u2009ng\/mL), while all six (100%) had elevated cystatin C levels (median 4.15\u2009mg\/L). Peripheral oxygen saturation was suboptimal in five subjects. All subjects had low hemoglobin concentration levels (median 8.5 g\/dL) while four had elevated white blood cell count. Although vaso\u2010occlusive crises result from microvessel occlusion, these findings at the macrovascular level suggest that SCD patients may also be vulnerable to mesenteric ischemic injury, especially in the setting of anemic heart failure from hemolysis.<\/jats:p>","DOI":"10.1002\/jcu.22729","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T17:03:00Z","timestamp":1557248580000},"page":"501-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Doppler ultrasonographic evaluation of celiac and mesenteric arteries in subjects with sickle cell disease"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7832-3390","authenticated-orcid":false,"given":"Oluwagbemiga O.","family":"Ayoola","sequence":"first","affiliation":[{"name":"Department of Radiology Faculty of Clinical Sciences, Obafemi Awolowo University  Ile\u2010Ife Nigeria"},{"name":"Department of Radiology Obafemi Awolowo University Teaching Hospital  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahman A.","family":"Bolarinwa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion Faculty of Basic Sciences, Obafemi Awolowo University  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uvie U.","family":"Onakpoya","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Clinical Sciences, Obafemi Awolowo University  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5654-4002","authenticated-orcid":false,"given":"Chidiogo C.","family":"Onwuka","sequence":"additional","affiliation":[{"name":"Department of Radiology Obafemi Awolowo University Teaching Hospital  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tewogbade A.","family":"Adedeji","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology Faculty of Basic Sciences, Obafemi Awolowo University  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babalola I.","family":"Afolabi","sequence":"additional","affiliation":[{"name":"Department of Radiology Obafemi Awolowo University Teaching Hospital  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-3505","authenticated-orcid":false,"given":"Stephen O.","family":"Onigbinde","sequence":"additional","affiliation":[{"name":"Department of Radiology Obafemi Awolowo University Teaching Hospital  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatiu A.","family":"Arogundade","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Clinical Sciences, Obafemi Awolowo University  Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"280","article-title":"American Gastroenterological Association medical position statement: guidelines on intestinal ischemia","volume":"119","author":"Brandt L","year":"2000","journal-title":"Gastrenterology"},{"key":"e_1_2_7_3_1","first-page":"1527","article-title":"Acute mesenteric artery occlusion\u2014clinical aspects, therapy, prognosis","volume":"110","author":"Braun L","year":"1985","journal-title":"Zentralbl Chir"},{"key":"e_1_2_7_4_1","first-page":"543","article-title":"Acute intestinal ischemia. 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