{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:32:55Z","timestamp":1775237575059,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health Committee of Sichuan Province","award":["17PJ389"],"award-info":[{"award-number":["17PJ389"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to investigate myocardial dysfunction and mechanical abnormalities in young patients with Graves' disease before therapy, using two\u2010dimensional speckle tracking echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a comprehensive transthoracic echocardiographic examination, including segmental and global radial strain, and time\u2010to\u2010peak radial strain, in 47 young patients with hyperthyroidism and 34 healthy adults. The time\u2010to\u2010peak radial strain was corrected by RR interval. The variables derived from radial myocardial deformation by the six\u2010basal, six\u2010mid, and six\u2010apical segmental model were compared to investigate the difference of the myocardial function between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Early diastolic mitral inflow velocity, E\/A ratio, early diastolic mitral annular velocity, and e\u2032\/a\u2032 ratio were lower in patients with Graves' disease than in controls. The left ventricular end\u2010diastolic volume, left ventricular end\u2010systolic volume, stroke volume, cardiac output, heart rate, late diastolic mitral inflow velocity, and late diastolic mitral annular velocity were slightly higher in patients than in controls. Radial strain, global radial strain, and corrected time\u2010to\u2010peak radial strain were lower in the patient group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The decreased radial strain, global radial strain, and corrected time\u2010to\u2010peak radial strain in young patients with newly diagnosed hyperthyroidism due to Graves' disease could serve as an early sign of subclinical cardiac involvement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22802","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T09:11:16Z","timestamp":1576228276000},"page":"216-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Changes in left ventricular function and contractile homogeneity in young adults with newly diagnosed hyperthyroidism due to Graves' disease"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0864-9512","authenticated-orcid":false,"given":"Mi","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Ultrasound in Medicine Sichuan Provincial People's Hospital Affiliate Wenjiang Hospital  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Sichuan Provincial People's Hospital Affiliate Wenjiang Hospital  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound and Non\u2010invasive Cardiology Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Xue","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound and Non\u2010invasive Cardiology Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si\u2010Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound and Non\u2010invasive Cardiology Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Meishan Second People's Hospital  Chengdu Sichuan 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