{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:05:43Z","timestamp":1757311543112,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We aimed to study the safety and feasibility of low\u2010dose dobutamine stress echocardiography in a symptomatic high gradient aortic stenosis population scheduled for transfemoral transcatheter aortic valve implantation (TAVI) and to quantify left ventricular (LV) flow reserve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty patients underwent dobutamine stress echocardiography with 5 minutes increments of 5 \u03bcg\/kg\/min up to 20\u2009\u03bcg\/kg\/min until the heart rate increased \u226520\u2009beats\/min from baseline or exceeded 100\u2009beats\/min. Other criteria for discontinuing the infusion were major adverse events: ventricular arrhythmia, persistent supraventricular arrhythmia, pulmonary edema, chest pain with significant ST\u2010changes, or minor events: ST\u2010changes, drop in systolic blood pressure &gt;30\u2009mmHg, mild chest pain, and\/or dyspnea. LV flow reserve was defined as an increase in stroke volume \u226520% during the test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 50 patients, 45 completed the test according to protocol. No patient had major adverse event. Five patients experienced minor side effects: mild chest pain\/dyspnea in three, self\u2010terminating atrial flutter in one, and decrease in blood pressure in one. Significant LV flow reserve was observed in 20 patients (40%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010dose dobutamine stress test appeared safe and feasible patients with high gradient aortic stenosis, and showed LV flow reserve in a minority of them.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22915","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T09:58:43Z","timestamp":1607075923000},"page":"38-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety and feasibility of dobutamine stress echocardiography in symptomatic high gradient aortic stenosis patients scheduled for transcatheter aortic valve implantation"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3683-5291","authenticated-orcid":false,"given":"Marte","family":"S\u00e6vik","sequence":"first","affiliation":[{"name":"The Intervention Centre, Rikshospitalet Oslo University Hospital  Oslo Norway"},{"name":"Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan O.","family":"Beitnes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rikshospitalet Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Aaberge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rikshospitalet Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per S.","family":"Halvorsen","sequence":"additional","affiliation":[{"name":"The Intervention Centre, Rikshospitalet Oslo University Hospital  Oslo Norway"},{"name":"Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw225"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz275"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000379"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"e000879","DOI":"10.1136\/openhrt-2018-000879","article-title":"Guideline\u2010defined futility or patient\u2010reported outcomes to assess treatment success after TAVI: what to use? 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