{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:17:24Z","timestamp":1784758644867,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apert syndrome is characterized by craniosynostosis, mid\u2010facial hypoplasia, and symmetric syndactyly. Prenatal diagnosis is challenging until the skull and facial anomalies become more pronounced during the third trimester. We present a case in which typical sonographic signs of Apert syndrome were observed after 23\u2009weeks of gestation. Following termination of the pregnancy, both clinical features such as craniofacial abnormalities and syndactyly and cranial 3D\u2010CT images showed high correlation with the previous sonographic findings. Furthermore, genetic analysis revealed a spontaneous mutation, c.755C\u2265G (p.S252W), in the FGFR2 gene, with this mutation implicated in the etiology of Apert syndrome.<\/jats:p>","DOI":"10.1002\/jcu.22927","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T12:09:02Z","timestamp":1600690142000},"page":"250-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Apert syndrome: A case report of prenatal ultrasound, postmortem cranial <scp>CT<\/scp>, and molecular genetic analysis"],"prefix":"10.1002","volume":"49","author":[{"given":"Weixia","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ultrasonography Hebei General Hospital  Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Hebei General Hospital  Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Hebei General Hospital  Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1335-7477","authenticated-orcid":false,"given":"Yuquan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Hebei General Hospital  Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Hebei General Hospital  Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"issue":"4","key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1542\/peds.41.4.829","article-title":"Craniosynostosis: a review of 519 surgical patients","volume":"41","author":"Shillito JR","year":"1968","journal-title":"Pediatrics"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1539"},{"key":"e_1_2_5_4_1","first-page":"238","article-title":"Two specimens of congenital cranial deformity in infants associated with fusion of fingers and toes","volume":"45","author":"Wheaton SW","year":"1894","journal-title":"Trans Pathol Soc London"},{"key":"e_1_2_5_5_1","volume-title":"Apert Syndrome","author":"Conrady CD","year":"2020"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1986.tb00516.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000181186"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/RUQ.0b013e3181fe7484"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14060426.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.844"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075135"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971112)72:4<394::AID-AJMG4>3.0.CO;2-R"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1758"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1294"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2648"},{"issue":"5","key":"e_1_2_5_16_1","first-page":"181","article-title":"Comparative three\u2010dimensional analysis of CT\u2010scans of the calvaria and cranial base in Apert and Crouzon syndromes. 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