{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:58:14Z","timestamp":1781294294774,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While immune checkpoint inhibitors (ICIs) have antitumor effects, they also have characteristic side effects, including colitis. However, gastritis has rarely been reported. We report a case of a patient with lung adenocarcinoma who presented with epigastric pain and diarrhea following pembrolizumab administration. Sonography of the abdomen demonstrated diffuse, although mild, gastric wall thickening (mainly in the submucosa), as well as a slight decrease in echogenicity throughout the gastric wall. While the mucosal surface was relatively smooth, color Doppler examination showed increased vascularity. Esophagogastroduodenoscopy and pathological examination confirmed the diagnosis of ICI\u2010related gastroenteritis.<\/jats:p>","DOI":"10.1002\/jcu.22975","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T15:30:16Z","timestamp":1613316616000},"page":"605-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A case of immune checkpoint <scp>inhibitor\u2010associated<\/scp> gastroenteritis detected by ultrasonography"],"prefix":"10.1002","volume":"49","author":[{"given":"Satomi","family":"Omotehara","sequence":"first","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine Hokkaido University Hospital  Sapporo Japan"},{"name":"Diagnostic Center for Sonography Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8406-7311","authenticated-orcid":false,"given":"Mutsumi","family":"Nishida","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine Hokkaido University Hospital  Sapporo Japan"},{"name":"Diagnostic Center for Sonography Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Yamanashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Katsurada","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Cancer Center Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Diagnostic Center for Sonography Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naofumi","family":"Shinagawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Sugita","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine Hokkaido University Hospital  Sapporo Japan"},{"name":"Department of Hematology, Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Teshima","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine Hokkaido University Hospital  Sapporo Japan"},{"name":"Department of Hematology, Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06441-w"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/tgh.2019.09.05"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14363"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2017-000278"},{"key":"e_1_2_5_6_1","unstructured":"BrierleyJD.TNM classification of malignant umours. In:GospodarowiczMK WittekindC eds. .8th ed.Chichester:John Wiley & Sons Ltd.;2017."},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.0391"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0702-611"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx286"},{"key":"e_1_2_5_10_1","first-page":"e1344805","article-title":"Incidence of immune checkpoint inhibitor\u2010related colitis in solid tumor patients: a systematic review and meta\u2010analysis","volume":"6","author":"Wang DY","year":"2017","journal-title":"Onco Targets Ther"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000213"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0864-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3335"},{"key":"e_1_2_5_14_1","first-page":"3406437","article-title":"Anti\u2010PD\u20101 therapy\u2010associated perforating colitis","author":"Celli R","year":"2018","journal-title":"Case Rep Gastrointest Med"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0411-1"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0346-6"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-019-00211-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6385"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx225"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951X-24-19"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2017.57"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491862"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.334"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2020.04.006"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i16.1971"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2263012080"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2018.04.018"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14029"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13963"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.22975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcu.22975","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.22975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:11:18Z","timestamp":1693415478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.22975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,12]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/jcu.22975"],"URL":"https:\/\/doi.org\/10.1002\/jcu.22975","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,12]]},"assertion":[{"value":"2020-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}