{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:40:53Z","timestamp":1786538453953,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"publisher","award":["QNRC2016237"],"award-info":[{"award-number":["QNRC2016237"]}],"id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical value of three\u2010dimensional ultrasound (3D\u2010US) with reformatting technique in the diagnosis of fetal cleft lip\/palate (CL\/P), especially those involving the secondary palate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 113 fetuses suspected with cleft lip (CL) on two\u2010dimensional ultrasound (2D\u2010US) were further evaluated by 2D\u2010US and 3D\u2010US with reformatting technique, in order to clarify the type of oral cleft. Lesions were classified as cleft lip (CL), cleft lip and alveolus (CLA), and cleft lip and palate (CLP) (including primary and secondary palate). All fetuses were followed until birth or termination of pregnancy. The diagnostic accuracies of 2D\u2010US and 3D\u2010US with reformatting technology were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both 2D\u2010US and 3D\u2010US with reformatting successfully detected CLs in the final 103 participants. Among these, 29, 25, and 49 cases were confirmed to have CL, CLA, and CLP, respectively. CL, CLA, and CLP were diagnosed by 2D\u2010US in 34, 66, and 3 cases, respectively, and by 3D\u2010US with reformatting technology in 31, 27, and 45 cases, respectively. The sensitivities of 2D\u2010US and 3D\u2010US with reformatting technology in the diagnosis of CLA were 80% (20\/25) and 92.0% (23\/25), respectively, and the difference was not statistically significant. For CLP, however, the sensitivities were 6.1% (3\/49) and 91.8% (45\/49), respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both 2D\u2010US and 3D\u2010US with reformatting technique have high diagnostic accuracy for CL and CLA. However, 3D\u2010US has a much higher diagnostic accuracy for CLP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.22994","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T06:56:54Z","timestamp":1614927414000},"page":"307-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The application of three\u2010dimensional ultrasound with reformatting technique in the diagnosis of fetal cleft lip\/palate"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-0819","authenticated-orcid":false,"given":"Chunya","family":"Ji","sequence":"first","affiliation":[{"name":"Center for Medical Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Medical Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-3564","authenticated-orcid":false,"given":"Linliang","family":"Yin","sequence":"additional","affiliation":[{"name":"Center for Medical Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedong","family":"Deng","sequence":"additional","affiliation":[{"name":"Center for Medical Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Pan","sequence":"additional","affiliation":[{"name":"Center for Medical Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal 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