{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:00:06Z","timestamp":1777424406340,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Systemic sclerosis (SSc) is associated with right ventricle (RV) remodeling and dysfunction. The primary aim of this study was to evaluate RV dyssynchrony (RV\u2010Dys) in SSc patients using two\u2010dimensional speckle tracking echocardiography (2D\u2010STE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010five SSc patients with functional class I\u2010II and 45 healthy controls were consecutively included and underwent 2D\u2010STE. RV\u2010Dys was defined as the standard deviation of time to peak strain of mid and basal segments of RV free wall and interventricular septum. SSc group was further classified according to the presence of pulmonary arterial hypertension (PAH). Patients with tricuspid regurgitant velocity &gt;2.8\u00a0m\/s with additional echocardiographic PAH signs were defined as SSc PAH (+).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SSc patients had lower RV longitudinal strain (RV\u2010LS) (\u221217.6\u2009\u00b1\u20094.6% vs. \u221220.8\u2009\u00b1\u20092.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and greater RV\u2010Dys (49.9\u2009\u00b1\u200925.4\u00a0ms vs 24.3\u2009\u00b1\u200911.8\u00a0ms, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.006) than controls despite no significant difference in conventional echocardiographic variables regarding RV function. Although SSc PAH(+) patients had lower RV\u2010LS and higher RV\u2010Dys than SSc PAH(\u2212) patients, the differences were not statistically significant. The only independent predictor of RV\u2010Dys was RV\u2010LS (\u03b2:\u20100.324 [\u22123.89\u2013 \u22120.45]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SSc patients had not only reduced RV\u2010LS but also impaired RV synchronicity even as conventional echocardiographic variables were preserved.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23041","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T09:16:20Z","timestamp":1626254180000},"page":"895-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The evaluation of right ventricle dyssynchrony by speckle tracking echocardiography in systemic sclerosis patients"],"prefix":"10.1002","volume":"49","author":[{"given":"Murat","family":"Demirci","sequence":"first","affiliation":[{"name":"Department of Cardiology Marmara University School of Medicine  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