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An earlier marker of LV systolic dysfunction is therefore needed and first phase EF (EF1) is a promising new candidate. It is the EF measured over early systole to the point of maximum transaortic blood flow. It may be low in the presence of preserved total LV EF since the heart may compensate by recruiting myosin motors in later systole. The EF1 is inversely related to the grade of AS and directly related to markers of subendocardial fibrosis like late gadolinium enhancement on cardiac magnetic resonance scanning. A reduced EF1 (&lt;25%) predicts adverse clinical events better that total EF and global longitudinal strain. We suggest that it is worth exploring as an indication for surgery in patients with asymptomatic severe AS.<\/jats:p>","DOI":"10.1002\/jcu.23063","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T10:53:38Z","timestamp":1631271218000},"page":"932-935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["First phase ejection fraction in aortic stenosis: A useful new measure of early left ventricular systolic dysfunction"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-5019","authenticated-orcid":false,"given":"Sahrai","family":"Saeed","sequence":"first","affiliation":[{"name":"Department of Heart Disease Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haotian","family":"Gu","sequence":"additional","affiliation":[{"name":"BHF Centre of Research Excellence King's College London  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