{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:13Z","timestamp":1786977973221,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the possible influence of chest wall conformation on myocardial strain parameters in a consecutive population of infants with pectus excavatum (PE), noninvasively assessed by modified Haller index (MHI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen consecutive PE infants (MHI &gt;2.5) and 44 infants with normal chest shape (MHI \u22642.5) entered in this prospective case\u2013control study. All infants underwent evaluation by neonatologist, transthoracic echocardiography implemented with two\u2010dimensional speckle tracking echocardiography (2D\u2010STE) analysis of both ventricles and MHI assessment (ratio of chest transverse diameter over the distance between sternum and spine), at two time points: within 3\u2009days and at about 40\u2009days of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 2.1\u2009\u00b1\u20091\u2009days of life, compared to controls (MHI\u00a0=\u00a02.01\u2009\u00b1\u20090.2), PE infants (MHI\u00a0=\u00a02.76\u2009\u00b1\u20090.2) were diagnosed with significantly smaller cardiac chambers dimensions. Biventricular contractile function and hemodynamics were similar in both groups of infants. Left ventricular (LV) global longitudinal strain (GLS) (\u221216.0\u2009\u00b1\u20092.8 vs. \u221221.7\u2009\u00b1\u20092.2%), LV\u2010global circumferential strain (GCS) (\u221216.3\u2009\u00b1\u20092.7 vs. \u221224.0\u2009\u00b1\u20095.2%), LV\u2010global radial strain (GRS) (24.2\u2009\u00b1\u20093.0 vs. 31.5\u2009\u00b1\u20096.3%), and right ventricular free wall longitudinal strain (RVFWLS) (\u221216.0\u2009\u00b1\u20093.2 vs. \u221222.3\u2009\u00b1\u20094.4%) were significantly reduced in PE infants versus controls (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A strong inverse correlation between MHI and the following parameters: LV\u2010GLS (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.92), LV\u2010GCS (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.88), LV\u2010GRS (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.87), and RVFWLS (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.88), was demonstrated in PE infants, but not in controls, in perinatal period (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Analogous results were obtained at 36.8\u2009\u00b1\u20095.2\u2009days after birth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Abnormal chest anatomy progressively impairs myocardial strain parameters in PE infants. This impairment might reflect intraventricular dyssynchrony due to compressive phenomena rather than intrinsic myocardial dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.23064","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T06:00:25Z","timestamp":1631685625000},"page":"918-928","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Does chest wall conformation influence myocardial strain parameters in infants with pectus excavatum?"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7641-8831","authenticated-orcid":false,"given":"Andrea","family":"Sonaglioni","sequence":"first","affiliation":[{"name":"Department of Cardiology IRCCS MultiMedica Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luigi","family":"Nicolosi","sequence":"additional","affiliation":[{"name":"Department of 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