{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:48:38Z","timestamp":1792190918418,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Muscle ultrasound (MUS) is an emerging noninvasive tool to identify fasciculations in amyotrophic lateral sclerosis (ALS). We assessed the utility of MUS in detecting fasciculations in suspected ALS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010three patients (25 men) with possible (<jats:italic>n<\/jats:italic>\u00a0=\u00a07), probable (<jats:italic>n<\/jats:italic>\u00a0=\u00a012), or definite ALS according to Awaji criteria were studied. Electromyography was done in biceps brachii, quadriceps, and thoracic paraspinal muscles and MUS in biceps, triceps, deltoid, abductor\u2010digiti\u2010minimi, quadriceps, hamstrings, tibialis anterior, thoracic paraspinal, and tongue muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The age at onset and illness duration was 49.73\u2009\u00b1\u200912.7\u2009years and 13.57\u2009\u00b1\u20099.7\u00a0months, respectively. Limb\u2010onset\u00a0=\u00a024 patients (72.7%) and bulbar\u2010onset\u00a0=\u00a09 (27.3%). Totally 561 muscles were examined by MUS. Fasciculations were detected in 84.3% of muscles, 98.4% with and 73% without clinical fasciculations (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Fasciculation detection rate (FDR) by MUS was significantly higher in muscles with wasting (95.6%) than without wasting (77.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Compared with EMG, FDR was significantly higher with MUS in quadriceps (81.8% vs. 51.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and thoracic paraspinal muscles (75.8% vs. 42.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.013). The proportion of patients with definite ALS increased from 42% by clinical examination to 70% after combining EMG and MUS findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MUS is more sensitive in detecting fasciculations than electromyography (EMG) and provides a safer, faster, painless, and noninvasive alternative to EMG in detecting fasciculations in ALS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23084","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T04:59:59Z","timestamp":1634533199000},"page":"286-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Muscle ultrasonography in detecting fasciculations: A noninvasive diagnostic tool for amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"50","author":[{"given":"Rahul Reddy","family":"Rajula","sequence":"first","affiliation":[{"name":"Department of Neurology National Institute of Mental Health And Neurosciences (NIMHANS)  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitender","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of NeuroImaging and Interventional Radiology National Institute of Mental Health And Neurosciences (NIMHANS)  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopikrishnan","family":"Unnikrishnan","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health And Neurosciences (NIMHANS)  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seena","family":"Vengalil","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health And Neurosciences (NIMHANS)  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saraswati","family":"Nashi","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health And Neurosciences (NIMHANS)  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-409X","authenticated-orcid":false,"given":"Mainak","family":"Bardhan","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health And Neurosciences (NIMHANS)  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshata","family":"Huddar","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health And Neurosciences (NIMHANS)  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanushree","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health And Neurosciences (NIMHANS)  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dodmalur Malikarjuna","family":"Sindhu","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health And Neurosciences (NIMHANS)  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valakunja Harikrishna","family":"Ganaraja","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health And Neurosciences (NIMHANS)  Bengaluru India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Polavarapu","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute; 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