{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:09:11Z","timestamp":1769090951791,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["Z2021071"],"award-info":[{"award-number":["Z2021071"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diffuse sclerosing variant of papillary thyroid carcinoma (DSV\u2010PTC) has ultrasound findings that are similar to Hashimoto's thyroiditis (HT), resulting in under\u2010diagnosis. DSV\u2010PTC combined with HT is also common, so early and accurate diagnosis of DSV\u2010PTC using a variety of diagnostic techniques, including FNAC, BRAF<jats:sup>V600E<\/jats:sup> mutation detection, and ultrasound elastography, is critical.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the diagnostic value of fine\u2010needle aspiration cytology (FNAC) and BRAF<jats:sup>V600E<\/jats:sup> detection in combination with ultrasound elastography in the diagnosis of DSV\u2010PTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of 40 patients with pathologically confirmed DSV\u2010PTC and 43 patients with HT admitted to our hospital's ultrasound department between January 2015 and December 2020. Preoperative FNAC, BRAF<jats:sup>V600E<\/jats:sup> mutation detection, and ultrasound elastography imaging were all performed on all patients. For a definitive diagnosis, the results of these tests were compared to postoperative pathological findings. The diagnostic value of FNAC, BRAF<jats:sup>V600E<\/jats:sup> mutation detection, ultrasound elasticity imaging, and their combination for DSV\u2010PTC diagnosis was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean elastic strain rate ratio (E1\/E2) of the 40 DSV\u2010PTC cases was 5.75\u2009\u00b1\u20092.14, while that of the 43 HT cases was 2.81\u2009\u00b1\u20091.20. The receiver operating characteristic (ROC) curve was generated using the average value of E2\/E1. The area under the ROC curve was 0.910, and the optimal E2\/E1 cut\u2010off value was 4.500. When FNAC, BRAF<jats:sup>V600E<\/jats:sup> mutation detection, and ultrasound elasticity imaging detection were combined, the diagnostic sensitivity, specificity, negative predictive value, positive predictive value, and accuracy of DSV\u2010PTC diagnosis were 92.5%, 95.3%, 93.2%, 94.9%, and 94.0%, respectively, which were significantly higher than the single technique (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of FNAC, BRAF<jats:sup>V600E<\/jats:sup> mutation detection, and ultrasound elastography in combination is more helpful in establishing an accurate diagnosis of DSV\u2010PTC than using a single diagnostic technique alone.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23260","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T17:33:25Z","timestamp":1656783205000},"page":"942-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Differential diagnosis of diffuse sclerotic thyroid papillary carcinoma and Hashimoto's thyroiditis using fine\u2010needle aspiration cytology, BRAF<sup>V600E<\/sup>, and ultrasound elastography"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-2545","authenticated-orcid":false,"given":"Xian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ultrasound Affiliated People's Hospital of Jiangsu University  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiju","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated People's Hospital of Jiangsu University  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-8759","authenticated-orcid":false,"given":"Juan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated People's Hospital of Jiangsu University  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-8555","authenticated-orcid":false,"given":"Enock Adjei","family":"Agyekum","sequence":"additional","affiliation":[{"name":"School of Medicine Jiangsu University  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology Affiliated People's Hospital of Jiangsu University  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated People's Hospital of Jiangsu University  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology head and Neck Surgery Affiliated People's Hospital of Jiangsu University  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Affiliated Hospital of Jiangsu University  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shudong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital, Jiangnan University  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated People's Hospital of Jiangsu University  Zhenjiang 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