{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:10:01Z","timestamp":1790971801961,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the application value of combined intravenous contrast\u2010enhanced ultrasound (IV\u2010CEUS) with intrabiliary contrast\u2010enhanced ultrasound (IB\u2010CEUS) in the preoperative evaluation of hilar cholangiocarcinoma (HCCA) resectability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data from 82 patients with HCCA confirmed by surgery and pathology were retrospectively analyzed. Preoperative IV\u2010CEUS\u2009+\u2009IB\u2010CEUS and magnetic resonance cholangiopancreatography (MRCP) were performed and the results were compared with surgical and pathological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The accuracy of the Bismuth\u2010Corlette classification confirmed by IV\u2010CEUS\u2009+\u2009IB\u2010CEUS and MRCP was 95.12% (78\/82) and 87.8% (72\/82), respectively. The diagnostic precision of IV\u2010CEUS\u2009+\u2009IB\u2010CEUS was better than MRCP (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). The sensitivity, specificity, and precision of CEUS for diagnosing lymph node metastases (72.7%, 93.3%, and 87.8%), intrahepatic metastases (78.6%, 98.5%, and 93.9%), invasion of the hepatic artery (92.9%, 98.5%, and 97.6%) and invasion of the portal vein (93.8%, 98.5%, and 97.6%) of HCCA were, respectively. The consistency between the preoperative evaluation of resectability confirmed by IV\u2010CEUS\u2009+IB\u2010CEUS and MRCP was 85.4% (70\/82) and 78.0% (64\/82), respectively. In addition, the evaluations did not have statistically significant differences (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). There were no significant differences between the two evaluations (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.266).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IV\u2010CEUS combined with IB\u2010CEUS has significant value in classifying HCCA and evaluating the resectability of lymph node metastases, liver metastases, and vessel invasion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23268","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T06:45:25Z","timestamp":1657349125000},"page":"931-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intravenous combined with intrabiliary contrast\u2010enhanced ultrasound in the evaluation of resectability of hilar cholangiocarcinomas"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1202-1928","authenticated-orcid":false,"given":"Wang","family":"Jianxiong","sequence":"first","affiliation":[{"name":"Department of Ultrasound Integrated Traditional Chinese and Western Medicine Hospital of Tianjin University, Tianjin Nankai Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Integrated Traditional Chinese and Western Medicine Hospital of Tianjin University, Tianjin Nankai Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Juyi","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Integrated Traditional Chinese and Western Medicine Hospital of Tianjin University, Tianjin Nankai Hospital  Tianjin 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