{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:58:25Z","timestamp":1776711505354,"version":"3.51.2"},"reference-count":83,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Left atrial (LA) dysfunction seems to play a central role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF), is associated with disease severity and poor outcomes and potentially impacts management. Identifying LA myopathy can help guide tailored therapy for HFpEF. Echocardiography allows the accurate measurement of atrial size and function, where LA strain appears to be a sensitive measure of intrinsic LA myopathy. Several therapies and devices that decompress of left atrium are being tested for HFpEF. Further investigation is required to understand the specific atrial effects of statins, mineralocorticoid receptor antagonists, and other therapies.<\/jats:p>","DOI":"10.1002\/jcu.23318","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T11:33:59Z","timestamp":1665488039000},"page":"1073-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Left atrial dysfunction as the major driver of heart failure with preserved ejection fraction syndrome"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3285-6148","authenticated-orcid":false,"given":"Artem G.","family":"Ovchinnikov","sequence":"first","affiliation":[{"name":"Out\u2010Patient Department, Institute of Clinical Cardiology National Medical Research Center of Cardiology named after Academician E.I. Chazov  Moscow Russia"},{"name":"Department of Clinical Functional Diagnostics, A.I. Yevdokimov Moscow State University of Medicine and Dentistry  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Potekhina","sequence":"additional","affiliation":[{"name":"Out\u2010Patient Department, Institute of Clinical Cardiology National Medical Research Center of Cardiology named after Academician E.I. Chazov  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-0829","authenticated-orcid":false,"given":"Evgeny","family":"Belyavskiy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow \u2010 Klinikum \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gvozdeva","sequence":"additional","affiliation":[{"name":"Out\u2010Patient Department, Institute of Clinical Cardiology National Medical Research Center of Cardiology named after Academician E.I. Chazov  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fail","family":"Ageev","sequence":"additional","affiliation":[{"name":"Out\u2010Patient Department, Institute of Clinical Cardiology National Medical Research Center of Cardiology named after Academician E.I. Chazov  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.08.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107038"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S207117"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.011031"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.01.016"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001667"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.055"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.83"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.05.018"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.12.005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008291"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90832-T"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12375"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90195-7"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.70.1.9"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.05.005"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006267"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024825"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.60.1.30"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.3.978"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.212787"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/24748706.2017.1353718"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.05.031"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-301388"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.126"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz641"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.11.003"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003754"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.147"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002763"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.04.006"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey042"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1464"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.08.014"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(64)90210-4"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.4.427"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.080"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1399"},{"key":"e_1_2_12_41_1","doi-asserted-by":"crossref","first-page":"e005467","DOI":"10.1161\/CIRCIMAGING.116.005467","article-title":"Influence of left atrial function on exercise capacity and left ventricular function in patients with heart failure and preserved ejection fraction","volume":"10","author":"Von Roeder M","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1399-8"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.189118"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.141656"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.971"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.108.813071"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-8-14"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.12.034"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu219"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-018-1425-y"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa415"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(81)90002-0"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.07.012"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab834"},{"issue":"1","key":"e_1_2_12_55_1","first-page":"1743","article-title":"The contribution of left atrial dysfunction to exercise intolerance in early heart failure with preserved left ventricular ejection fraction","volume":"21","author":"Ovchinnikov AG","year":"2019","journal-title":"Eur Heart J Cardiovasc Imag"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu165"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz713"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy268"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.0136"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.08.050"},{"issue":"2","key":"e_1_2_12_61_1","first-page":"S186","article-title":"In patients with elevated LV filling pressure loop diuretics improve severity of heart failure and diastolic dysfunction, but torasemide does it somewhat better than furosemide","volume":"10","author":"Azizova AG","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.01.029"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84133-9"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000568"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001475"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu193"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.008461"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002729"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy809"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018614"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034646"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.092"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016795"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.06.022"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90788-M"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00539-6"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.001229"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032094"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.059486"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.10.011"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.02.022"},{"issue":"1","key":"e_1_2_12_82_1","first-page":"418","article-title":"Statins improves functional capacity and restores LV diastolic reserve in patients with heart failure with preserved left ventricular ejection fraction","volume":"21","author":"Ovchinnikov AG","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx739"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.05.005"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.23318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcu.23318","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.23318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T09:47:23Z","timestamp":1692611243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.23318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":83,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/jcu.23318"],"URL":"https:\/\/doi.org\/10.1002\/jcu.23318","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2022-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}