{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:14:35Z","timestamp":1765808075587,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Cardiac involvement in limb\u2010girdle muscular dystrophy (LGMD)2A and LGMD2B, the most common subgroups of LGMD, is controversial. Our study aims to determine whether myocardial dysfunction develops in LGMD2A and LGMD2B patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 16 LGMD2A, 12 LGMD2B patients, and 48 healthy individuals. Comparisons included demographic, clinical, and laboratory parameters of LGMD2A and LGMD2B subgroups and traditional echocardiography and two\u2010dimensional speckle tracking echocardiography (2D\u2010STE) parameters with the normal population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 33 (22\u201339 interquartile range [IQR]) in the LGMD2A group, 33 (27\u201338 IQR) in the LGMD2B group, and 28 (25\u201335 IQR) in the control group. The left ventricular (LV) ejection fraction of both LGMD2A and LGMD2B groups was similar to the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.296 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.918). Apical 4\u2010chamber longitudinal strain (LS), Apical 2\u2010chamber LS, Apical 3\u2010chamber LS, left ventricular global longitudinal strain (LVGLS)\u2010mid\u2010myocardial, LVGLS\u2010endocardium, and LVGLS\u2010epicardium were lower (less negative) in the LGMD2B group compared to the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LV 2D\u2010STE parameters of LGMD2A patients were similar to the control group, while they decreased significantly (less negative) in LGMD2B patients, indicating that LV subclinical myocardial dysfunction may develop in LGMD2B patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23323","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T14:39:03Z","timestamp":1662647943000},"page":"1242-1248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of cardiomyopathy with <scp>two\u2010dimensional<\/scp> speckle tracking echocardiography in limb\u2010girdle muscular dystrophy type <scp>2A<\/scp> and <scp>2B<\/scp>"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2491-6593","authenticated-orcid":false,"given":"Abdurrahman","family":"Aky\u00fcz","sequence":"first","affiliation":[{"name":"Department of Cardiology University of Health Sciences Gazi Ya\u015fargil Training and Research Hospital  Diyarbak\u0131r 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