{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:43:30Z","timestamp":1787676210156,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We examine the use of transvaginal sonography in imaging ovarian follicles among non\u2010pregnant reproductive\u2010aged women enrolled in a contraceptive clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten sites conducted a clinical trial comparing three oral ulipristal acetate regimens for ovulation inhibition. Enrollees underwent twice weekly transvaginal sonography and hormonal blood testing throughout treatment and until the second menses post\u2010treatment. The primary outcome of the present analysis was success in identifying follicles \u226510\u2009mm in a subgroup of sonograms performed at times of likely follicular activity (estradiol &lt;100\u2009pg\/ml and progesterone &gt;3\u00a0ng\/ml). Secondarily, an overall analysis assessed all sonograms regardless of timing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At times of likely follicular activity, 135 women underwent 969 sonograms. The proportion of sonograms without follicles \u226510\u2009mm ranged from 8.3% to 46.3% when stratified by site (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). The odds of no follicle among higher\u2010body mass index (BMI) women were 1.91 times those among lower\u2010BMI women after controlling for site and treatment arm (95% CI: 1.13, 3.22). Results were similar for the overall population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sonographers were less likely to identify follicles for higher\u2010BMI women and results varied by site. Machine quality slightly impacted sonogram results, but did not sufficiently explain site differences.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23405","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T16:49:46Z","timestamp":1670690986000},"page":"454-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Using transvaginal ultrasounds for the identification of follicle\u2010like structures \u226510\u2009mm in a multi\u2010center randomized contraceptive clinical trial of three 84\u2010day oral ulipristal acetate regimens"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-0576","authenticated-orcid":false,"given":"Jessica D.","family":"Rosenberg","sequence":"first","affiliation":[{"name":"Department of Epidemiology Columbia University Mailman School of Public Health  New York New York USA"},{"name":"Guttmacher Institute<sup>\u2020<\/sup>  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3622-8846","authenticated-orcid":false,"given":"Carolyn L.","family":"Westhoff","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Columbia University Mailman School of Public Health  New York New York USA"},{"name":"Department of Obstetrics and Gynecology Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2014.08.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18945"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2816"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2022.04.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.04.248"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1648420"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2014.08.011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1993.03060422.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.10.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP15748.DSCPT2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.03.036"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.326125510"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567202614666170718095203"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.670332"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12311"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.23405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcu.23405","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.23405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T13:55:17Z","timestamp":1702043717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.23405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,10]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/jcu.23405"],"URL":"https:\/\/doi.org\/10.1002\/jcu.23405","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,10]]},"assertion":[{"value":"2022-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}