{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:54:47Z","timestamp":1773104087501,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018534","name":"Medical Innovation Project of Fujian Province","doi-asserted-by":"publisher","award":["2014\u2010CX\u201017"],"award-info":[{"award-number":["2014\u2010CX\u201017"]}],"id":[{"id":"10.13039\/501100018534","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is a need today for favorable biomarkers to follow up on the disease progression and therapeutic response in patients with Duchenne muscular dystrophy (DMD). This study evaluates whether quantitative muscle ultrasound (QMUS) or magnetic resonance imaging (MRI) is more suitable for the assessment of DMD in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010six boys with DMD, who were treated with prednisone from baseline to month 12, were enrolled in this longitudinal, observational cohort study. Muscle thickness and echo intensity on QMUS and T1\u2010weighted MRI grading were measured in the right rectus femoris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Scores for muscle thickness and echo intensity in QMUS and T1\u2010weighted MRI grading showed significant correlations with the clinical characteristics of muscle strength, timed testing, and quality of life (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Scores for muscle thickness and echo intensity on QMUS also showed good correlations with T1\u2010weighted MRI grading (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, 15 of 36 boys with DMD did not undergo MRI examinations for various reasons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>QMUS and MRI can be used as biomarkers for tracking DMD to some extent. Both have strengths and weaknesses and the specific needs and goals of the clinical or research project are what make one preferable to the other.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23411","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T18:12:57Z","timestamp":1669831977000},"page":"674-679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantitative muscle ultrasound in children with <scp>D<\/scp>uchenne muscular dystrophy: Comparing to magnetic resonance imaging"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3122-5195","authenticated-orcid":false,"given":"Jun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Key Laboratory of Pediatrics in Chongqing  Chongqing China"},{"name":"Chongqing International Science Technology Cooperations Center for Child Development and Disorders  Chongqing China"},{"name":"Department of Neurology, Children's Hospital Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqi","family":"Hong","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Key Laboratory of Pediatrics in Chongqing  Chongqing China"},{"name":"Chongqing International Science Technology Cooperations Center for Child Development and Disorders  Chongqing China"},{"name":"Department of Neurology, Children's Hospital Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Cheng","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Key Laboratory of Pediatrics in Chongqing  Chongqing China"},{"name":"Chongqing International Science Technology Cooperations Center for Child Development and Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Key Laboratory of Pediatrics in Chongqing  Chongqing China"},{"name":"Chongqing International Science Technology Cooperations Center for Child Development and Disorders  Chongqing China"},{"name":"Department of Ultrasound, Children's Hospital Chongqing Medical University  Chongqing 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Children's Hospital Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zou","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Key Laboratory of Pediatrics in Chongqing  Chongqing China"},{"name":"Chongqing International Science Technology Cooperations Center for Child Development and Disorders  Chongqing China"},{"name":"Molecular Medicine Center, Children's Hospital Chongqing Medical University  Chongqing 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