{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:19:54Z","timestamp":1747149594159,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnosis of intrathoracic and abdominal masses is challenging when lesions are located behind major vessels. Endoscopic ultrasound (EUS) or endobronchial ultrasound (EBUS)\u2010guided transvascular needle aspiration (TVNA) provides a potentially useful diagnostic tool for such lesions. Data with respect to the safety and outcome of E\u2010TVNA are scarce. Hence, this meta\u2010analysis was conducted to assess the critical role of E\u2010TVNA for diagnosis of various lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Material<\/jats:title><jats:p>A meta\u2010analysis was performed by pooling the data from studies obtained from comprehensive search of Medline, Embase, and Scopus from January 2000 to September 2022. The outcomes analyzed included sample adequacy, diagnostic accuracy and adverse events including bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 17 studies (<jats:italic>n<\/jats:italic>\u00a0=\u00a0411) were included in the final analysis. The pooled rate of sample adequacy was 91.5% [95% confidence interval (CI): 86.8\u201396.2], while the pooled rate of diagnostic accuracy was 85.0% (95% CI: 78.9\u201391.2). The pooled rate of bleeding with E\u2010TVNA was 1.4% (95% CI 0.0\u20133.1%). All the episodes of bleeding were mild and resolved without any further intervention. There was no significant heterogeneity with respect to various outcomes and results were comparable on sensitivity analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>E\u2010TVNA offers a safe and accurate diagnostic modality for the diagnosis of mediastinal and abdominal lesions located on the other side of major vessels. Selection of potential candidates and close periprocedural observation are essential to improve the outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23441","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T17:39:25Z","timestamp":1676396365000},"page":"723-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of endosonography\u2010guided transvascular needle aspiration of thoracic and abdominal lesions: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9626-5243","authenticated-orcid":false,"given":"Suprabhat","family":"Giri","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Nizam's Institute of Medical Sciences  Hyderabad 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