{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:38:56Z","timestamp":1767832736230,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Systemic amyloidosis is an uncommon disorder in which amyloid fibrils deposit extracellularly. Three\u2010dimensional speckle\u2010tracking echocardiography (3DSTE) is a novel method able to assess left ventricular (LV) global longitudinal strain (GLS). Our aim was to evaluate the prognostic impact of 3DSTE\u2010derived LV\u2010GLS in patients with cardiac amyloidosis (CA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 35 patients suffering from light\u2010chain (AL) CA or transthyretin (TTR) CA were selected, but 7 patients had to be excluded due to insufficient image quality or were lost for follow\u2010up. With AL\u2010CA 23 cases, while for TTR\u2010CA 5 patients were diagnosed. Complete two\u2010dimensional Doppler and 3DSTE were performed in all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up was 201\u2009days (ranging from 36 to 632\u2009days) during which cardiovascular event was detected in 17 CA patients, including 8 cardiac deaths. Six patients were diagnosed with acute heart failure, two patients needed invasive interventions (percutaneous coronary intervention with stent\u2010implantation, implantable cardioverter defibrillator implantation) and in one patient new higher grade atrioventricular block was registered. Using ROC analysis, 3DSTE\u2010derived LV\u2010GLS\u2009\u226511.8% (absolute value) was found to be a significant predictor for cardiovascular event\u2010free survival (sensitivity 65%, specificity 64%, area under the curve 0.71, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.05). Lower LV ejection fraction was confirmed in patients with LV\u2010GLS\u2009&lt;11.8% as compared to cases with LV\u2010GLS\u2009\u226511.8%. In case of a cardiovascular event, LV\u2010GLS was lower as compared to that of subjects with no events. Multivariable regression analysis confirmed that LV\u2010GLS and LV end\u2010diastolic diameter were independent predictors of cardiovascular survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>3DSTE\u2010derived LV\u2010GLS is an independent predictor for future cardiovascular events in CA patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23445","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T06:08:10Z","timestamp":1677305290000},"page":"952-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic role of three\u2010dimensional speckle\u2010tracking echocardiography\u2010derived left ventricular global longitudinal strain in cardiac amyloidosis: Insights from the <scp>MAGYAR\u2010Path<\/scp> 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