{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:49:22Z","timestamp":1790304562651,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aim to study the MRI features of pituitary adenoma (PA) apoplexy and their relationship with hypoxia, proliferation, and pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven patients with MRI signs of PA apoplexy were selected. According to the MRI signs, they were divided into the parenchymal group and the cystic group. The parenchymal group had a low signal area on T2WI without cyst &gt;2\u2009mm and this area was not significantly enhanced on the corresponding TW1 enhancement. The cystic group had a cyst &gt;2\u2009mm on T2WI, and the cyst showed liquid stratification on T2WI or high signal on T1WI. The relative T1WI (rT1WI) enhancement value and relative T2WI (rT2WI) value of non\u2010apoplexy areas were measured. Protein levels of hypoxia\u2010inducible factor\u20101 (HIF\u20101\u03b1), pyruvate dehydrogenase kinase 1 (PDK1), and Ki67 were detected with immunohistochemistry and Western blot. Nuclear morphology was observed with HE staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rT1WI enhancement average value, rT2WI average value, Ki67 protein expression level, and the number of abnormal nuclear morphology of non\u2010apoplexy lesions in the parenchymal group were significantly lower than those in the cystic group. The protein expression levels of HIF\u20101\u03b1 and PDK1 in the parenchymal group were significantly higher than those in the cystic group. HIF\u20101\u03b1 protein was positively correlated with PDK1 but negatively correlated with Ki67.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When there is PA apoplexy, the ischemia and hypoxia of the cystic group are lesser than those of the parenchymal group, but the proliferation is stronger.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23492","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T17:06:03Z","timestamp":1685120763000},"page":"1078-1086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>MRI<\/scp> features of pituitary adenoma apoplexy and their relationship with hypoxia, proliferation, and pathology"],"prefix":"10.1002","volume":"51","author":[{"given":"Jianwu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery 900 Hospital of the Joint Logistics Team  Fuzhou People's Republic of 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