{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:27:31Z","timestamp":1788600451385,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate whether the diffusion tensor imaging (DTI) parameters alterations in the in hypoxia\u2010related neuroanatomical localizations in patients after COVID\u201019. Additionally, the relationship between DTI findings and the clinical severity of the disease is evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patients with COVID\u201019 were classified into group 1 (total patients, <jats:italic>n<\/jats:italic>\u2009=\u200974), group 2 (outpatient, <jats:italic>n<\/jats:italic>\u2009=\u200946), and group 3 (inpatient, <jats:italic>n<\/jats:italic>\u2009=\u200928) and control (<jats:italic>n<\/jats:italic>\u2009=\u200952). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were calculated from the bulbus, pons, thalamus, caudate nucleus, globus pallidum, putamen, and hippocampus. DTI parameters were compared between groups. Oxygen saturation, D dimer and lactate dehydrogenase (LDH) values associated with hypoxia were analyzed in inpatient group. Laboratory findings were correlated with ADC and FA values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased ADC values in the thalamus, bulbus and pons were found in group 1 compared to control. Increased FA values in the thalamus, bulbus, globus pallidum and putamen were detected in group 1 compared to control. The FA and ADC values obtained from putamen were higher in group 3 compared to group 2. There was a negative correlation between basal ganglia and hippocampus FA values and plasma LDH values. The ADC values obtained from caudate nucleus were positively correlated with plasma D Dimer values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ADC and FA changes may reveal hypoxia\u2010related microstructural damage after COVID\u201019 infection. We speculated that the brainstem and basal ganglia can affected during the subacute period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23503","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T10:03:40Z","timestamp":1686305020000},"page":"1276-1283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Microstructural alterations in hypoxia\u2010related BRAIN centers after COVID\u201019 by using DTI: A preliminary study"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-4418","authenticated-orcid":false,"given":"Serdar","family":"Balsak","sequence":"first","affiliation":[{"name":"Department of Radiology Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-5876","authenticated-orcid":false,"given":"Bahar","family":"Atasoy","sequence":"additional","affiliation":[{"name":"Department of Radiology Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Donmez","sequence":"additional","affiliation":[{"name":"Department of Radiology Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Celik","family":"Yabul","sequence":"additional","affiliation":[{"name":"Department of Radiology Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrettin","family":"Da\u015fkaya","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Akkoyunlu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail","family":"Yurtsever","sequence":"additional","affiliation":[{"name":"Department of Radiology Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00fctfullah","family":"Sar\u0131","sequence":"additional","affiliation":[{"name":"Department of Radiology Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Sijahovic","sequence":"additional","affiliation":[{"name":"Department of Radiology Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Akcay","sequence":"additional","affiliation":[{"name":"Department of Radiology Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Toluk","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpay","family":"Alkan","sequence":"additional","affiliation":[{"name":"Department of Radiology Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100484"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04575-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14726"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.387"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2021.02.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246817"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075740"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30308-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02070-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.05.024"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05082-9"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"3080","article-title":"The association of posterior reversible encephalopathy syndrome with COVID\u201019: a systematic review","volume":"72","author":"Iftikhar S","year":"2021","journal-title":"Ann Med Surg (Lond)"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","unstructured":"ChenR WangK YuJ ChenZ WenC XuZ.The spatial and cell\u2010type distribution of SARS\u2010CoV\u20102 receptor ACE2 in human and mouse brain. bioRxiv2020; 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