{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:57:34Z","timestamp":1790564254390,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This system review and meta\u2010analysis was aim to evaluate the accuracy of prenatal ultrasound in diagnosing cleft palates (CPs) during first trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Source<\/jats:title><jats:p>We systematically searched the databases of PubMed, Embase, and Cochrane Library for the articles, which assessed the accuracy of CPs diagnosed by ultrasound during first trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Method<\/jats:title><jats:p>The characteristics of the included studies were recorded. The quality of included studies was assessed by QUADAS\u20102. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the curve (AUC) were calculated using Meta\u2010Disc software version 1.4. The publication bias was assessed by Stata software version 12.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This meta\u2010analysis included 13 studies with 39\u2009806 fetuses. The pooled sensitivity, specificity, PLR, NLR were 0.874, 0.999, 689.84, and 0.161, respectively. The DOR and AUC were 6651.3 and 0.9084, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The overall detection rate was 0.874, which indicated high value of first trimester ultrasound in diagnosing CPs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23507","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T18:22:31Z","timestamp":1686594151000},"page":"1015-1023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The performance of first\u2010trimester ultrasound in diagnosing fetal cleft palate: Meta\u2010analysis and systematic review"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-4541","authenticated-orcid":false,"given":"Dongmei","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Obstetrics The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ultrasound Qingdao Women and Chlidren's Hospital  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Ultrasound The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2642"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780121403"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta9120"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7484"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10139"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15675"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369797"},{"key":"e_1_2_7_11_1","first-page":"1911","article-title":"Two\u2010dimensional sonographic findings of cleft palate in early pregnancy","volume":"33","author":"Gan L","year":"2017","journal-title":"Chin J Med Imag Technol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.16.05084"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.12891\/ceog3406.2017"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481773"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5257"},{"key":"e_1_2_7_16_1","first-page":"1520","article-title":"Ultrasonic observation on palatal line in early pregnancy for screening fetal cleft lip and palate","volume":"37","author":"He G","year":"2021","journal-title":"Chin J Med Imag Technol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22123"},{"key":"e_1_2_7_18_1","first-page":"531","article-title":"First\u2010trimester evaluation of cleft lip and palate by a novel two\u2010dimensional sonographic technique: a prospective study","volume":"38","author":"Li X","year":"2022","journal-title":"Curr Med Imaging"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350181"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21931"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.08.050"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_472_20"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5794"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22994"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3954"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.23507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T22:08:53Z","timestamp":1692482933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.23507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,12]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/jcu.23507"],"URL":"https:\/\/doi.org\/10.1002\/jcu.23507","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,12]]},"assertion":[{"value":"2023-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}