{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:14:13Z","timestamp":1775067253913,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Develop charts for cavum septum pellucidi (CSP) following a standardized methodology and using quantile regression. The secondary objective was to assess the influence of fetal gender on the generated reference curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional prospective study 453 low\u2010risk singleton pregnancies were evaluated at a gestational age interval between 18 and 34\u2009weeks. The width of CSP were measured on ultrasound images using a standardized technique and their changes were evaluated by quantile regression as a function of gestational age (GA) interval or head circumference (HC). Differences between sex were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The measurement of CSP significantly increased with gestation and HC. Linear models better described the changes of CSP with GA and HC. The fits of CSP width with GA and HC were not significantly different. Male fetuses showed significantly higher CSP width when compared to female fetuses (<jats:italic>u<\/jats:italic>\u2009=\u20092.973; <jats:italic>p<\/jats:italic>\u2009=\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We generated prospective nomograms of fetal CSP development using quantile regression and following a strict standardized methodology. These new charts may be useful to better identify abnormal cases at higher risk of associated anomalies. Further our findings underline the potential effect of gender in developing fetal brain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23533","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T08:48:09Z","timestamp":1691398089000},"page":"1466-1471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Modeling fetal cavum septum pellucidi width by quantile regression at 18\u201334\u2009weeks of gestation: A prospective cross\u2010sectional study"],"prefix":"10.1002","volume":"51","author":[{"given":"Chiara","family":"Patelli","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Universit\u00e0 diVerona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-9048","authenticated-orcid":false,"given":"Giorgia","family":"Berti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universit\u00e0 Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Chiara","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universit\u00e0 Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5962-2846","authenticated-orcid":false,"given":"Jia Li Angela","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universit\u00e0 Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Resta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universit\u00e0 Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilenia","family":"Mappa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universit\u00e0 Tor Vergata  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Pulsatility Index nomograms from different maternal and fetal vessels by quantile regression at 24\u201040\u2009weeks of gestation: a prospective cross\u2010sectional study","volume":"35","author":"Rizzo G","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1919091117"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2016.1149565"},{"issue":"49","key":"e_1_2_8_22_1","first-page":"14","article-title":"Fetal intracranial structures: differences in size according to sex","volume":"15","author":"Kavak EC","year":"2021","journal-title":"J Perinat Med"}],"container-title":["Journal of Clinical 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