{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:20:12Z","timestamp":1747149612945,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate the effect of diabetes mellitus (DM) on the association between Galectin\u20103 (Gal\u20103) and the H2FPEF score in patients with unexplained dyspnea and a preserved left ventricular ejection fraction (LVEF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional observational study was conducted on patients with unexplained dyspnea and a preserved LVEF in the Cardiology Department of Elaz\u0131g Medical Park Hospital, Turkey. The patients were evaluated based on the presence of DM and the H2FPEF score. Gal\u20103 levels were compared between groups, and the effect of DM on Gal\u20103 was assessed. The level of statistical significance in all tests was set at<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gal\u20103 and H2FPEF scores were higher in patients with DM (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 and<jats:italic>p<\/jats:italic>\u2009=\u2009.027, respectively). Gal\u20103 and HbA1C values were elevated in patients with moderate to high H2FPEF scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01 and<jats:italic>p<\/jats:italic>\u2009=\u2009.036, respectively). DM and Hypertension were more prevalent in patients with moderate to high H2FPEF scores (<jats:italic>p<\/jats:italic>\u2009=\u20090.024,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). A strong correlation was observed between Gal\u20103 and the H2FPEF score (<jats:italic>r<\/jats:italic>\u2009=\u20090.375,<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Gal\u20103 could predict patients with a moderate to high H2FPEF score using a cut\u2010off value of 14.7, with a sensitivity of 69% and specificity of 67% (AUC: 0.702).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gal\u20103 serves as an independent predictor of the H2FPEF score in the presence of DM, and the diagnostic capability of Gal\u20103 for Heart Failure with preserved LVEF remains unaffected by DM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23559","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T09:46:59Z","timestamp":1694425619000},"page":"1429-1435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of diabetes mellitus on association between galectin\u20103 and<scp>H2FPEF<\/scp>score in patients with unexplained dyspnea and a preserved left ventricular ejection fraction"],"prefix":"10.1002","volume":"51","author":[{"given":"Orhan","family":"Dogdu","sequence":"first","affiliation":[{"name":"Department of Cardiology Medical Park Hospital Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1713-3451","authenticated-orcid":false,"given":"Mehdi","family":"Karasu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fethi Sekin \u015eehir Hastanesi Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y\u00fccel","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fethi Sekin \u015eehir Hastanesi Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Harman","sequence":"additional","affiliation":[{"name":"Department of Cardiology F\u0131rat \u00dcniversitesi T\u0131p Fak\u00fcltesi Elazig 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