{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:39:32Z","timestamp":1773351572151,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aims to determine whether second\u2010trimester uterine artery (UtA) Doppler combined with first\u2010trimester abnormal pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) and \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010Hcg) levels predicts adverse obstetric and neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study of 289 pregnant women included 196 with normal PAPP\u2010A and free \u03b2\u2010HCG values (control group) and 93 with abnormal values (study group) in the first\u2010trimester screening test. Second\u2010trimester UtA Doppler sonography was done in these pregnancies. The perinatal prediction and screening potential of UtA Doppler pulsatility index (PI) parameters were examined in the study group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>UtA PI &gt;95 percentile increased birth before the 37th week by 4.46 times, birth before the 34th week by 7.44 times, preeclampsia risk by 3.25 times, fetal growth restriction (FGR) risk by 4.89 times, and neonatal intensive care unit (NICU) admission rates by 3.66 times in the study group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for all). UtA PI &gt;95 percentile had 49.2% sensitivity and 82.1% specificity for birth before 37\u2009weeks. For birth before 34\u2009weeks, sensitivity was 80.0% and specificity 65.0%. FGR has 70.5% sensitivity and 67.1% specificity. Screening for preeclampsia has 66.6% sensitivity and 61.9% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adding UtA Doppler in the second trimester to pregnancies with abnormal PAPP\u2010A and\/or free \u03b2\u2010Hcg values in the first trimester may be a useful screening method for adverse outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23644","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T10:26:20Z","timestamp":1707906380000},"page":"394-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The role of second trimester uterine artery Doppler in predicting obstetric and neonatal outcomes in abnormal first trimester maternal serum pregnancy\u2010associated plasma <scp>protein\u2010A<\/scp> and free \u03b2\u2010human chorionic gonadotropin values"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-4644","authenticated-orcid":false,"given":"Yusuf","family":"Dal","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Mersin University Faculty of Medicine  Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-9165","authenticated-orcid":false,"given":"Fatih","family":"Akku\u015f","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Necmettin Erbakan University Meram Faculty of Medicine  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2339-1609","authenticated-orcid":false,"given":"\u015eebnem","family":"Karag\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Mersin University Faculty of Medicine  Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-0212","authenticated-orcid":false,"given":"Ahmet Zeki","family":"Nessar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Mersin University Faculty of Medicine  Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1595-2621","authenticated-orcid":false,"given":"Sefanur Gamze","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Mersin University Faculty of Medicine  Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2887-9649","authenticated-orcid":false,"given":"Ayhan","family":"Co\u015fkun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Mersin University Faculty of Medicine  Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5332"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3876"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2015.12.007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.1002763"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.794779"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.052"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.068"},{"issue":"4","key":"e_1_2_12_9_1","first-page":"559","article-title":"One\u2010stage screening for pregnancy complications by color Doppler assessment of the uterine arteries at 23\u2009weeks' 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