{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:36:23Z","timestamp":1775738183398,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the efficacy of atrioventricular valve regurgitation (AVVR) for predicting atrioventricular septal defect (AVSD) in the first trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective observational study, screening for complicated congenital heart diseases and AVVR in fetuses at 11 to 13<jats:sup>+6<\/jats:sup> weeks of gestation by advanced dynamic flow in four\u2010chamber view and three\u2010vessel\u2010trachea view.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>43\u2009549 fetuses at 11 to 13<jats:sup>+6<\/jats:sup> weeks of gestation were screened by echocardiography, of which 37 cases were diagnosed with AVSD, including complete AVSD (31 cases), intermediate AVSD (3 cases) and partial AVSD (1 cases), undiagnosed intermediate AVSD (2 cases), and misdiagnosed case (2 cases). AVVR was observed in 34 cases (34\/37) in the first trimester, 59. 46% (22\/37) nuchal translucency greater than 95th percentile, 29. 73% (11\/37) absence of nasal bone, 32. 43% (12\/37) ductus venosus A wave inversion, and 40. 54% (15\/37) had tricuspid regurgitation. The sensitivity of common AVVR in predicting AVSD is better than other ultrasonic indexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AVVR can be used as an ultrasonic indicator to predict AVSD in the first trimester, which is beneficial to detect AVSD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23651","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T09:38:51Z","timestamp":1708076331000},"page":"405-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of atrioventricular valve regurgitation in the first trimester for the diagnosis of atrioventricular septal defect"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4493-8469","authenticated-orcid":false,"given":"Shuihua","family":"Yang","sequence":"first","affiliation":[{"name":"Maternity &amp; Child Healthcare Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengfeng","family":"Liang","sequence":"additional","affiliation":[{"name":"Maternity &amp; Child Healthcare Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guican","family":"Qin","sequence":"additional","affiliation":[{"name":"Maternity &amp; Child Healthcare Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanni","family":"Tang","sequence":"additional","affiliation":[{"name":"Maternity &amp; Child Healthcare Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"Maternity &amp; Child Healthcare Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulan","family":"Pang","sequence":"additional","affiliation":[{"name":"Maternity &amp; Child Healthcare Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuojian","family":"Yang","sequence":"additional","affiliation":[{"name":"Maternity &amp; Child Healthcare Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_2_10_3_1","first-page":"129","volume-title":"Echocardiographie f\u0153tale","author":"Boussion F","year":"2013"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.11152\/mu-879"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.4.585"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5"},{"key":"e_1_2_10_7_1","unstructured":"NicolaidesKH.The fetal medicine foundation. 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