{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:20:29Z","timestamp":1747149629519,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multi\u2010systemic metastasis in patients with Peutz\u2010Jeghers syndrome (PJS) is very rare, and there are nearly no relevant imaging reports, especially in contrast\u2010enhanced ultrasound (CEUS). We present here a 40\u2010year\u2010old male patient who underwent several partial small bowel resections and endoscopic polypectomy for intestinal polyps. After reviewing the patient's clinical diagnosis and treatment process, CEUS with sulfur hexafluoride microbubbles (SonoVue, Bracco, Milan, Italy) in the liver and gastrointestinal tract was performed. We imaged multiple abnormal masses with sonographic features consistent with malignancies. Combined with other imaging examinations and 18 gauge core\u2010needle puncture biopsy of liver masses, multiple metastases outside the gastrointestinal tract were considered. This case report suggests CEUS may be an easy, effective, and supplementary method for evaluating PJS patients with suspected multi\u2010systemic malignant lesions including the gastrointestinal tract.<\/jats:p>","DOI":"10.1002\/jcu.23677","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T07:39:44Z","timestamp":1711611584000},"page":"649-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contrast\u2010enhanced ultrasound of polyp malignant transformation with multiple metastases in a patient with <scp>Peutz\u2010Jeghers<\/scp> syndrome"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1888-2294","authenticated-orcid":false,"given":"Xiangyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Air Force Medical Center Air Force Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Air Force Medical Center Air Force Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilian","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Air Force Medical Center Air Force Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Air Force Medical Center Air Force Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhou","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Air Force Medical Center Air Force Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2018.11.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14740\/gr1130"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520212"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-017-1399-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2017.09.016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.05.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00573-17"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10823"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.725"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205121"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2023.108511"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-239100"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-011-9738-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1809"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl14044"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5397"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i10.1627"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.23677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T05:59:24Z","timestamp":1723183164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.23677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/jcu.23677"],"URL":"https:\/\/doi.org\/10.1002\/jcu.23677","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"type":"print","value":"0091-2751"},{"type":"electronic","value":"1097-0096"}],"subject":[],"published":{"date-parts":[[2024,3,28]]},"assertion":[{"value":"2023-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}