{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T21:09:09Z","timestamp":1774040949924,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine the cerebro\u2010placental\u2010uterine ratio (CPUR) in pregnant women with pregestational diabetes and determine its role in predicting adverse prenatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, cohort study conducted at a tertiary hospital included 65 patients with pregestational diabetes (25 with type1 diabetes, 40 with type2 diabetes) and 130 low\u2010risk patients in the control group. The cerebroplacental (CPR) ratio and the CPUR were calculated. Composite adverse perinatal outcome (CAPO) is defined as the presence of any of the following: (1) Neonatal intensive care unit (NICU) admission, (2) Apgar at 5\u2009min &lt;7, and (3) umbilical cord arterial pH &lt;7.10. The relationship of CPR and CPUR with CAPO was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CPR and CPUR were significantly lower in the pregestational diabetes group than in the control group. The NICU admission was higher in the case group. In receiver operating characteristic analyses, the optimal cut\u2010off value of CPUR was 1.46 (AUC\u2009=\u20090.72, <jats:italic>p<\/jats:italic>\u2009=\u20090.003, 80% sensitivity, and 69% specificity) to predict CAPO and the optimal cut\u2010off value of CPUR was 1.50 for NICU admission (AUC\u2009=\u20090.70, <jats:italic>p<\/jats:italic>\u2009=\u20090.013, 77% sensitivity, and 66% specificity).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low CPUR values were found to be associated with adverse perinatal outcomes in women with pregestational diabetes. With the increasing number of studies, CPUR is expected to be utilized more widely in routine obstetric practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23700","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T09:09:02Z","timestamp":1713949742000},"page":"745-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Utility of the cerebro\u2010placental\u2010uterine ratio in predicting composite adverse perinatal outcomes in pregestational diabetes: A prospective cohort study"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8726-1075","authenticated-orcid":false,"given":"Zahid","family":"Agaoglu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ministry of Health Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8209-8248","authenticated-orcid":false,"given":"Atakan","family":"Tanacan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ministry of Health Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8663-8053","authenticated-orcid":false,"given":"Goksun","family":"Ipek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ministry of Health Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6719-7335","authenticated-orcid":false,"given":"Ayca","family":"Peker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ministry of Health Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1283-4032","authenticated-orcid":false,"given":"Merve","family":"Ozturk Agaoglu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ministry of Health Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8362-7324","authenticated-orcid":false,"given":"Ayse Gulcin","family":"Bastemur","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ministry of Health Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4204-0014","authenticated-orcid":false,"given":"Ozgur","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ministry of Health Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-9048","authenticated-orcid":false,"given":"Dilek","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ministry of Health Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.24-3-e144"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002960"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14840"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191710846"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1719481"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-001966"},{"key":"e_1_2_10_8_1","unstructured":"ClearyEM ThungSF BuschurEO.Pregestational Diabetes Mellitus. 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