{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:43:56Z","timestamp":1768254236457,"version":"3.49.0"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:00:00Z","timestamp":1715990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This prospective study assessed the value of ultrasonography (US) in the evaluation of hepatosplenic fungal infections (HSFI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two pediatric participants with confirmed onco\u2010hematological diseases and HSFI were included. Lesions in the liver and\/or spleen were detected by US, magnetic resonance imaging (MRI), or computed tomography (CT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the participants, 11 (34%) had confirmed HSFI, while 21 (66%) had highly suspected HSFI. The US, CT, MRI, and fungal blood cultures demonstrated positive results in 31, 19, 25, and 7 patients, respectively. US had a significantly higher detection rate than CT, MRI, and fungal blood cultures (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The \u201c<jats:italic>bull's eye<\/jats:italic>\u201d phenomenon was a distinctive US feature of HSFI. Follow\u2010up examinations indicated that after a mean of 7.7 (1\u201315) months, liver and\/or spleen lesions disappeared in five patients. The lesion was significantly smaller in 10 patients. Residual calcifications were detected in 15 patients. Two patients died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Conclusively, the US may substitute for tissue biopsy, other imaging modalities, or fungal blood culture for the confirmation of HSFI, and may guide better antifungal treatment, thus achieving better outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23730","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T07:46:24Z","timestamp":1716018384000},"page":"866-874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ultrasonography is an effective method for evaluating hepatosplenic fungal infections in pediatric onco\u2010hematological patients"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-0468","authenticated-orcid":false,"given":"Wenhua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2074-3544","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Special Examination The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13106"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04125-z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12910"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pix046"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pix055"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23005"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S254478"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13083"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16452"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13066"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2011.01.022"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12838"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2018.01.011"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001431"},{"issue":"7","key":"e_1_2_11_17_1","first-page":"516","article-title":"Invasive fungal infections in children with Haematological malignancies: diagnostic and therapeutic challenges","volume":"7","author":"Tragiannidis A","year":"2021","journal-title":"Journal of Fungi (Basel, Switzerland)"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01487-19"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12038"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03713.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2004.10.003"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.02.023"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1996.tb00300.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000040869"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880020315"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.7017"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx030"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30723-3"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1515\/rjim-2017-0006"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00158"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13148"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.171.1.2538862"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2012.02182.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870220902"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.166.2.3275982"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3367-z"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900215)65:4<874::AID-CNCR2820650408>3.0.CO;2-Z"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1994.tb00397.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2019.09.005"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2010.08.005"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2016.01.005"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0019"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27564"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002010"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001468"},{"issue":"4","key":"e_1_2_11_48_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4274\/tjh.2014.0035","article-title":"Management of Invasive Fungal Infections in pediatric acute leukemia and the appropriate time for restarting chemotherapy","volume":"32","author":"T\u00fcfek\u00e7i \u00d6","year":"2015","journal-title":"Turkish J Haematol: Offic J Turkish Soc Haematol"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pix053"},{"issue":"6","key":"e_1_2_11_50_1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1055\/s-0037-1607194","article-title":"Surgical implications for diagnosis and treatment of intestinal aspergillosis in pediatric patients with ALL","volume":"28","author":"Fischer J","year":"2018","journal-title":"Eur J Pediatr Surg: Official J Austrian Association of Pediatr Surg [Et al] = Zeitschrift Fur Kinderchirurgie"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit006"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01728792"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1304625"}],"container-title":["Journal of Clinical Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcu.23730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:26:49Z","timestamp":1731587209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcu.23730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,18]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/jcu.23730"],"URL":"https:\/\/doi.org\/10.1002\/jcu.23730","archive":["Portico"],"relation":{},"ISSN":["0091-2751","1097-0096"],"issn-type":[{"value":"0091-2751","type":"print"},{"value":"1097-0096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,18]]},"assertion":[{"value":"2024-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}