{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:02:45Z","timestamp":1780466565214,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the value of prenatal diagnostic genetic testing in cases with isolated aberrant right subclavian artery (ARSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective cohort study, conducted between January 2015\u2013January 2022 in a fetal medicine center. Women who had an ultrasound scan and diagnosed with fetal ARSA were included. Ultrasonographic characteristics, genetic, obstetric, and neonatal outcomes were collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 240 fetuses with ARSA were identified and included to the analysis. Eighty\u2010two of the group had isolated ARSA (34.2%, 82\/240), 57 had additional soft markers (23.8%, 57\/240) and 101 had additional major ultrasonographic abnormalities (42.1%, 101\/240). Genetic results were available in 196 cases (81.7%, 196\/240). Seventy\u2010four of isolated ARSA cases underwent genetic testing (90.2%, 74\/82). A chromosomal abnormality was present in 60 cases; 54 (22.5%, 54\/240) aneuploidies and 6 (2.5%, 6\/240) copy number variants. Five (6.1%) of the isolated ARSA cases had chromosomal abnormalities. All of these five cases had prenatal genetic testing due to high\u2010risk aneuploidy screening fetuses who had ARSA with at least one additional anomaly had the highest chromosomal abnormality rate (38.6%, 39\/101). Seventy\u2010seven of isolated ARSA cases were liveborn (93.9%, 77\/82).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results supports the evidence from the literature that isolated ARSA confers a very low\u2010risk for aneuploidy, if the aneuploidy screening tests are low\u2010risk. Also, chromosomal microarray analysis did not yield any extra information in isolated ARSA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23770","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:18:56Z","timestamp":1722298736000},"page":"1096-1102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Aberrant right subclavian artery in the absence of other prenatal ultrasound findings: Should we still be concerned?"],"prefix":"10.1002","volume":"52","author":[{"given":"Ali \u015eahap","family":"Odac\u0131lar","sequence":"first","affiliation":[{"name":"Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Perinatology University of Health Sciences  Istanbul 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