{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:24:24Z","timestamp":1785875064606,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of the current study was to determine the difference in intestinal microbiota after delivery between healthy fetuses and fetuses with hyperechogenic bowel during the second trimester and the relationship between fetal echogenic bowel and microbiota.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen healthy fetuses (control group), 13 fetuses with echogenic bowel (EB group), and seven fetuses with echogenic bowel and other abnormalities (C\u2010EB group) were selected. The first meconium after delivery was collected for 16S rRNA sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1\u2009222\u2009131 high\u2010quality sequences were generated after sequencing optimization of all samples. Each sample contained an average of 35\u2009945 high\u2010quality sequences and 2036 operational taxonomic units (OTUs). There was no significant difference in the Shannon, Simpson index among the three groups. At the genus level, the abundance of <jats:italic>Escherichia coli<\/jats:italic>\/<jats:italic>Shigella<\/jats:italic> in the EB and C\u2010EB groups was significantly lower than the control group, while the abundance of <jats:italic>Staphylococcus<\/jats:italic>, <jats:italic>Methylobactrium<\/jats:italic>, and <jats:italic>Curvibacter<\/jats:italic> in the EB group was significantly higher than the other groups. There was a difference in abundance of <jats:italic>Gammaproteobacteria<\/jats:italic>, <jats:italic>Fusobacteria<\/jats:italic>, <jats:italic>Enterobacteriaceae<\/jats:italic>, and <jats:italic>E. coli<\/jats:italic> in the EB and C\u2010EB groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The formation of echogenic bowel may be related to the microbiota.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcu.23794","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T09:27:24Z","timestamp":1725010044000},"page":"1338-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fetal echogenic bowel may be related to intestinal microbiota: A prospective cohort 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