{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:27:59Z","timestamp":1792481279043,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Methotrexate (MTX) and leflunomide (LEF) play fundamental roles in rheumatoid arthritis (RA) treatment and require proper monitoring of side effects. Concerns about MTX\/LEF\u2010related liver fibrosis (LF) in patients with RA remain unclear. This study investigated liver stiffness using two\u2010dimensional shear wave elastography (2D\u2010SWE) in RA patients undergoing disease\u2010modifying antirheumatic drug (DMARD) therapy. Moreover, 2D\u2010SWE was employed to evaluate the correlations between liver stiffness, cumulative MTX and LEF doses and risk factors for substantial LF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We recruited 222 participants from the Department of Rheumatology. The participants were divided into healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200978) and patients with RA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009144). Pearson's correlation analysis was performed to assess the correlations between liver stiffness and the cumulative dose of MTX\/LEF and other clinical and laboratory variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean elasticity modulus was 4.79\u2009\u00b1\u20090.92\u2009kPa, excluding the presence of significant fibrosis. Mean 2D\u2010SWE values were significantly lower in healthy controls than in RA treated with MTX and LEF. The cut\u2010off \u22653.8\u2009kPa 2D\u2010SWE values with the sensitivity of 86.1%, specifity of 83.3%. 2D\u2010SWE values were not significantly different across the strata of the cumulative MTX subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MTX and LEF increase liver stiffness but may be considered low risk for the development of LF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.23847","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T22:39:33Z","timestamp":1726871973000},"page":"148-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of liver parenchyma with shear wave elastography in patients with rheumatoid arthritis receiving disease\u2010modifying antirheumatic drug therapy"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8295-9770","authenticated-orcid":false,"given":"Dilek","family":"Tezcan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, G\u00fclhane Faculty of Medicine University of Health Sciences Turkey  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1141-1094","authenticated-orcid":false,"given":"Halil","family":"\u00d6zer","sequence":"additional","affiliation":[{"name":"Division of Radiology Selcuk University Faculty of Medicine  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-1923","authenticated-orcid":false,"given":"\u00d6mer Faruk","family":"Topalo\u011flu","sequence":"additional","affiliation":[{"name":"Division of Radiology Selcuk University Faculty of Medicine  Konya 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