{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:59:24Z","timestamp":1772992764669,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Fetal liver calcifications (FLCs) are isolated or multiple areas of increased echogenicity in the fetal liver, with an estimated prevalence of 5\u201310 per 10\u2009000 births. However, their clinical importance remains still unclear. Although they are often linked to infections, chromosomal disorders, thrombotic events, or tumors, isolated FLCs generally have a favorable outcome. This article aims to present a case of a 29\u2010year\u2010old pregnant woman with a low\u2010risk cfDNA test, who presented for the first trimester screening scan at our hospital at 12\u2009weeks of pregnancy. The morphology scan at 20\u2009weeks and 5\u2009days revealed a normal fetal size with areas of increased echogenicity in the liver. No other fetal issues were identified. The patient was monitored throughout her pregnancy at our center, receiving genetic counseling and tests for detecting cystic fibrosis, STORCH (syphilis, cytomegalovirus, herpes virus 1;2, rubella, and toxoplasma), fetal echocardiography, and MRI, all of which were normal. At 35\u2009weeks and 6\u2009days, the patient gave birth to a healthy male, and all subsequent postnatal examinations confirmed the baby's health. This article aims to offer comprehensive insights into the management and postnatal outcomes of isolated FLCs, based on a review of the literature.<\/jats:p>","DOI":"10.1002\/jcu.23884","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T16:49:13Z","timestamp":1730134153000},"page":"163-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Isolated Fetal Liver Calcifications: Case Report and Literature Review"],"prefix":"10.1002","volume":"53","author":[{"given":"Martina","family":"Derme","sequence":"first","affiliation":[{"name":"Azienda Ospedaliero\u2010Universitaria Policlinico Umberto I  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6380-3009","authenticated-orcid":false,"given":"Adele","family":"Vasta","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health and Urological Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Caterina","family":"Corigliano","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero\u2010Universitaria Policlinico Umberto I  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Arn\u00f2","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health and Urological Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-1030","authenticated-orcid":false,"given":"Valentina","family":"D'Ambrosio","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero\u2010Universitaria Policlinico Umberto I  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Di Mascio","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health and Urological Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health and Urological Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Giancotti","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health and Urological Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.127899"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5152\/jtgga.2011.66"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/122.3.753"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651\u20102227.1989.tb11187.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/88.2.287"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010020\u201004678\u20101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.08.023"},{"key":"e_1_2_8_9_1","volume-title":"Obstetric Imaging; 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