{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:49:21Z","timestamp":1792003761907,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Ultrasound"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the effectiveness of contrast\u2010enhanced ultrasound (CEUS) and high\u2010frequency ultrasound (HFUS) in evaluating the efficacy of wrist intervention for rheumatoid arthritis (RA) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study enrolled rheumatoid arthritis (RA) patients experiencing wrist swelling and pain at the Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine, over the period from October 2021 to June 2024. All patients were given 1\u2009mL of compound betamethasone injection under ultrasound guidance, and the characteristics of wrist synovium CEUS and HFUS before and after treatment were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 49 patients (37 females, 53.45\u2009\u00b1\u200914.9\u2009years) were enrolled. Peak intensity (PI) was highly correlated with the 28\u2010joint disease activity score (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.798,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The display rate of CEUS for synovium of wrist joints was 100% 2\u2009weeks after treatment, while the display rate of PDUS for synovial blood flow was reduced to 65.31% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Receiver operating characteristic curve analysis revealed that the CEUS had an area under the curve (AUC) of 0.792 (95% CI: 0.666\u20130.918,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in predicting the therapeutic effect, with sensitivity and specificity of 52.2% and 96.2%, respectively. Moreover, HFUS had an AUC of 0.722 (95% CI: 0.577\u20130.867,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) in predicting the therapeutic effect, with sensitivity and specificity of 56.5% and 84.6%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CEUS and HFUS might be supplemental strategies in evaluating the therapeutic effect for RA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcu.23912","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T19:45:31Z","timestamp":1737402331000},"page":"631-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Value of Contrast\u2010Enhanced Ultrasound and High\u2010Frequency Ultrasound in Evaluating the Efficacy of Wrist Intervention for Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9482-223X","authenticated-orcid":false,"given":"Fan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Ultrasound Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rheumatism Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiling","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-018-0016-9"},{"key":"e_1_2_9_3_1","first-page":"22","article-title":"Steroid Use in the Treatment of Rheumatic and Regional Pain Disorders","volume":"2","author":"Goldenberg D.","year":"2022","journal-title":"Practical Pain Management"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.149765"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21641"},{"issue":"35","key":"e_1_2_9_6_1","first-page":"1123","article-title":"Ultrasound\u2010Guided Local Injection in Treatment of Hand and Wrist Tenosynovitis in Patients With Rheumatoid Arthritis","volume":"8","author":"Xu H.","year":"2019","journal-title":"Chinese Journal of Medical Imaging"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2021.1912905"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000260"},{"issue":"12","key":"e_1_2_9_9_1","first-page":"114","article-title":"Effect of Contrast\u2010Enhanced Ultrasonography and Power Doppler Ultrasonography in the Assessment of Synovitis in Patients With Rheumatoid Arthritis","volume":"1","author":"Gao C.","year":"2020","journal-title":"Chinese Journal of the Frontiers of Medical Science (Electronic Version)"},{"issue":"11","key":"e_1_2_9_10_1","article-title":"Optimizing Reliability of Real\u2010Time Sonographic Examination and Scoring of Joint Synovitis in Rheumatoid Arthritis","volume":"14","author":"Ranganath V. 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