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Color Doppler ultrasound and radiographic examination (CT and MRI) suggested that the mass arose from the left epididymis without tumor metastasis. The histopathological and immunohistochemical findings revealed a chrysanthemum\u2010like arrangement of round tumor cells, along with strong positive expression of CD99, vimentin, CD117, CD56, and Ki\u201067 (70%), supporting the diagnosis of primary epididymal Ewing sarcoma. The patient underwent surgical excision and received 3\u2009cycles of postoperative chemotherapy with vincristine, doxorubicin, and cyclophosphamide. The patient is recovering satisfactorily, and his follow\u2010up treatments and condition are being monitored.<\/jats:p>","DOI":"10.1002\/jcu.23936","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T04:46:45Z","timestamp":1740026805000},"page":"931-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primitive Ewing Sarcoma of Epididymis: A Case Report and Literature Review"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9110-1885","authenticated-orcid":false,"given":"Lan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Interventional Affiliated Hospital of Guizhou Medical University  Guiyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Interventional Affiliated Hospital of Guizhou Medical University  Guiyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Interventional Affiliated Hospital of Guizhou Medical University  Guiyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Interventional Affiliated Hospital of Guizhou Medical University  Guiyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-014-0687-z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12615"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0003-x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.210226"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2005.10.018"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2021.105676"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)01418-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000004392"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i13.4145"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2021.05.006"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000002992"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2019.03.006"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2019.0052"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patol.2017.10.002"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2017.10.023"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2015.11.007"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.140759"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2731"},{"issue":"5","key":"e_1_2_11_20_1","article-title":"Ewing's Sarcoma\/Primitive Neuroectodermal Tumour of the Prostate: A Case Report and Literature Review","volume":"7","author":"Wu T.","year":"2013","journal-title":"Canadian Urological Association Journal"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.107826"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7796.82180"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2009.02339.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.42518"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/57293350"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.5858\/2003-127-e190-PPPNTO"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000065880.06201.5c"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-023-01793-x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025074"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.591257"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.06.036"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2019.06.022"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896912454565"},{"issue":"5","key":"e_1_2_11_34_1","first-page":"932","article-title":"Primary Ewing's Sarcoma\/Primitive Neuroectodermal Tumor of the Urogenital Tract in Children","volume":"125","author":"Song H. 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